Results 191 to 200 of about 4,659,210 (298)

Structural Insights Into the Function of Leishmania major Adenylosuccinate Lyase. [PDF]

Proteins
E Silva IR, Mantovani M, Lino MESD, Albuquerque AO, da Silva JHM, Nagem RAP, Rojas AL, Sartori GR, Horjales E, Campbell D, Thiemann OH.   +10 more
europepmc   +1 more source

Stiffness‐Activated Stellate Cells Drive Pancreatic Cancer Liver Colonization via GMFG‐TNS4 Signaling

Advanced Science, EarlyView.
Fibrotic liver stiffness activates hepatic stellate cells through Piezo1‐dependent calcium influx and ER stress, promoting EV‐associated GMFG release. Delivered GMFG engages TNS4 in pancreatic cancer cells, triggering FAK/AKT signaling, adhesion, and fatty acid synthesis.
Biwen Zhu, Jian Wan, Xue Zhang, Jiashuai Yan, Xi Chen, Xiaoqi Guan, Qianqian Ren, Tao Yang, Di Wu, Qingsong Guo, Yibing Guo, Yuhua Lu   +11 more
wiley   +1 more source

Attitudes, stigma and knowledge on obesity in Mexico: a national cross-sectional survey of the general population and healthcare professionals living with or without obesity. [PDF]

Lancet Reg Health Am
Vázquez-Velázquez V, Mejía Domínguez NR, Mancillas-Adame LG, García-García E, Díaz GM, Montoya García JR, Flint SW.   +6 more
europepmc   +1 more source

Adipocyte Myoglobin Is a Determinant of Energy Expenditure and a Potential Target to Limit Obesity

Advanced Science, EarlyView.
Myoglobin, known as a muscle oxygen‐carrying protein, is shown to play a key role in fat cells that burn energy. Loss of myoglobin reduces the body's ability to generate heat and increases obesity risk, while restoring it improves metabolism. The study identifies myoglobin as a regulator of fat burning and a potential target to enhance energy ...
Christian Strehlau, Helen Broghammer, Claudia Gebhardt, Anne Hoffmann, Tobias Hagemann, Şeyma Midilli, Rachel S. Zimmer, Kristin Schubert, Vasiliki Karagiannakou, Anastasia Georgiadi, Mario Ost, Martin Krüger, Lisa Roth, Kerstin Krause, Nora Klöting, Maria Keller, Martin Wabitsch, Rima Nuwayhid, Roland H. Stimson, Michael Stumvoll, Matthias Blüher, Juliane Weiner, John T. Heiker   +22 more
wiley   +1 more source

Allopurinol in chronic kidney disease: navigating between pathophysiology, experimental evidence, and real-world challenges. [PDF]

J Bras Nefrol
Vargas-Santos AB, Telles RW, Castelar-Pinheiro GDR.   +2 more
europepmc   +1 more source

De Novo Designed Minibinders Targeting the GDF15–GFRAL Axis Reverse Cancer Cachexia and Restore Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐derived GDF15 drives cancer cachexia and suppresses antitumor immunity. Here, de novo designed minibinders targeting the GDF15–GFRAL interface achieve picomolar affinity and potent pathway blockade. The minibinders alleviate cachexia, restore CD8+ T‐cell infiltration, enhance anti–PD‐1 responsiveness, and provide survival benefits across tumor ...
Haitao Wang, Tianzhen Hua, Meiling Wang, Bingbing Meng, Yue Zhang, Chengxu Jiang, Yunhe Gao, Hongqi Yang, Jian Bo   +8 more
wiley   +1 more source

["It all starts with welcoming": access, acceptability and elements for the promotion of the health of adolescents and young people in primary care]. [PDF]

Cad Saude Publica
Guimarães J, Mendes VM, Almeida IS, Ayres JRCM.   +3 more
europepmc   +1 more source

Wearable‐Derived Diurnal Alignment Between Physical Activity and Device Temperature Predicts Future Disease and Mortality Risk

Advanced Science, EarlyView.
Wearable‐derived diurnal alignment between physical activity and device temperature, decomposed into 24 h coupling strength (M24), phase deviation (D24), and 12 h harmonic magnitude (M12), is examined in approximately 90,000 UK Biobank participants.
Han Chen, Jiahe Wei, Jonathan Cedernaes, Christian Benedict, Athanasios Tsanas, Zhi Cao, Xiao Tan   +6 more
wiley   +1 more source

O Estado Novo e a Nacionalização

, 2007
O artigo objetiva mostrar como diferentes agentes sociais e/ou "intelectuais orgânicos" a serviço do Estado Novo e com ele identificados discorreram sobre questões como nação, nacionalidade, nacionalismo, organização nacional, identidade nacional. Foram recuperadas falas anteriores a 10 de novembro de 1937, querendo-se com isso mostrar que há uma certa
openaire   +1 more source

A Complex Chromosome Rearrangement Disrupting <i>SYT1</i> Supports Haploinsufficiency as a Cause of Baker-Gordon Syndrome. [PDF]

Case Rep Genet
Bertola DR, Farias SO, da Costa SS, Pinheiro MMLS, Passos-Bueno MRDS, Rosenberg C, Krepischi ACV.   +6 more
europepmc   +1 more source