Results 231 to 240 of about 1,027,919 (286)

Haplotype‐Resolved 3D Genomic Landscapes and Their Impacts on Agronomic Traits in Grapevine

Advanced Science, EarlyView.
This study presents a haplotype‐resolved 3D genomic landscape of grapevine, revealing that structural variations (SVs) are closely associated with phased topologically associating domain (TAD) boundary transitions. These rearrangements coordinate with allele‐specific DNA methylation (ASM) and allele‐biased gene expression (ASE) to shape key agronomic ...
Yanling Peng, Lianzhu Zhou, Xinyue Fang, Ruoyan Zhao, Qi Xu, Mengrui Du, Ting Hou, Guizhou Huang, Yingchun Zhang, Sheng Yan, Ruo Yang, Zhongxin Jin, Yang Dong, Yanshuai Xu, Hua Xiao, Xiaodong Xu, Yi Liao, Xiping Wang, Yongfeng Zhou   +18 more
wiley   +1 more source

<i>De <i>N</i>ovo</i>-Designed Miniprotein Inhibits the Enzymatic Activity of the SARS-CoV-2 Main Protease. [PDF]

J Chem Inf Model
Lima TE, Moreira EG, Coêlho DF, Cruz CHB, Dhalia R, Leite BHS, Xavier LS, Illana MP, Wallau GL, Viana IFT, Lins RD.   +10 more
europepmc   +1 more source

Diffusion–Model–Driven Discovery of Ferroelectrics for Photocurrent Applications

Advanced Science, EarlyView.
We developed a diffusion model–based generative AI and high‐throughput screening framework that accelerates the discovery of photovoltaic ferroelectrics. By coupling AI driven crystal generation with machine learning and DFT screening, we identified Ca3P2 and LiCdP as new ferroelectric materials exhibiting strong polarization, feasible switching ...
Byung Chul Yeo, Hyun‐Jae Lee, Sungwoo Kang, Jung‐Hoon Lee   +3 more
wiley   +1 more source

Anthropogenic Barriers Limit Fish Access to Essential Habitats in the Amazon in the Face of Climate Change. [PDF]

Glob Chang Biol
Yofukuji KY, Fabrin TMC, Stabile BHM, Agostinho AA, Jézéquel C, Batista-Silva VF, Esser LF, Ferreira JHD, Ré R, Tedesco PA, Azevedo JC, Bailly D.   +11 more
europepmc   +1 more source

Ultrasound‐Activated Bifunctional Piezoelectric Hydrogel Dressings Promote Infected Wound Healing via Regulating Angiogenesis and Lymphangiogenesis

Advanced Science, EarlyView.
This study developed a double‐network hydrogel with piezoelectric properties, exhibiting excellent antibacterial activity and promoting fibroblast migration, angiogenesis, and lymphangiogenesis through piezoelectric stimulation, thereby accelerating the healing of infected chronic wounds.
Xiang Li, Zhen Ding, Zhihua Liu, Hao Chen, Jianyang Shan, Yanxuan Shao, Yaling Yu, Gen Wen   +7 more
wiley   +1 more source

A sedução das armas. Radicalização na contestação ao Estado Novo [PDF]

, 2016
Ferreira, Ana Sofia
core   +1 more source

Transcriptomic, proteomic and biochemical comparison of luminescent and non-luminescent Keroplatinae larvae (Diptera: Keroplatidae). [PDF]

Insect Mol Biol
Silva JR, Pelentir GF, Amaral DT, Stevani C, Viviani VR.   +4 more
europepmc   +1 more source

Cars2‐Mediated Cysteine Catabolism Drives Brown Fat Development and Thermogenesis Through Persulfidating EBF2

Advanced Science, EarlyView.
We demonstrate that Cars2, a cysteine catabolic enzyme in mouse iBAT, is critical for cold tolerance and brown adipocyte differentiation. Through its CPERS activity, Cars2 produces CysSSH/H2S to induce EBF2 persulfidation, promoting its interaction with PPARγ and BRG1 to enhance thermogenic gene expression.
Xin Peng, Hongyong Song, Yin Long, Kaimin Wu, Yinkun Fu, Wenkai Zhou, Wenyan Li, Zhe Shi, Xu‐Yun Zhao   +8 more
wiley   +1 more source

Quinazolinones as Bioisosteres of Naphthoquinones: A Path to Potent <i>Hs</i>DHODH Inhibitors with Optimized Properties. [PDF]

ACS Med Chem Lett
Godoi BF, Bueno JD, Silva WJL, da Purificação AD, Leite PIP, Dos Santos T, Freitas M, Silva DG, Silva TC, de Moraes J, Freitas CS, Mattos M, Souza TML, Martin BA, Lopez RFV, Nonato MC, Andrade CH, Emery FS.   +17 more
europepmc   +1 more source