Results 221 to 230 of about 6,674,734 (293)

Attitudes, stigma and knowledge on obesity in Mexico: a national cross-sectional survey of the general population and healthcare professionals living with or without obesity. [PDF]

Lancet Reg Health Am
Vázquez-Velázquez V, Mejía Domínguez NR, Mancillas-Adame LG, García-García E, Díaz GM, Montoya García JR, Flint SW.   +6 more
europepmc   +1 more source

Selective Modulation of OTUB1 Noncanonical Function via a bioPhosTAC Strategy

Advanced Science, EarlyView.
This work positions the versatile performance of the peptide‐based bioPhosTAC platform for dissecting phosphorylation‐dependent biology and expanding the scope of induced‐proximity technologies. We demonstrated that selective manipulation of a tyrosine phosphorylation site is sufficient to propagate coordinated cellular consequences.
Seung Un Seo, Seon Min Woo, Minhyeong Choi, Soeun Rhee, Simmyung Yook, Donghyuk Shin, Kwang‐Su Park, Taeg Kyu Kwon   +7 more
wiley   +1 more source

Allopurinol in chronic kidney disease: navigating between pathophysiology, experimental evidence, and real-world challenges. [PDF]

J Bras Nefrol
Vargas-Santos AB, Telles RW, Castelar-Pinheiro GDR.   +2 more
europepmc   +1 more source

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

A Complex Chromosome Rearrangement Disrupting <i>SYT1</i> Supports Haploinsufficiency as a Cause of Baker-Gordon Syndrome. [PDF]

Case Rep Genet
Bertola DR, Farias SO, da Costa SS, Pinheiro MMLS, Passos-Bueno MRDS, Rosenberg C, Krepischi ACV.   +6 more
europepmc   +1 more source

Streptococcal Mannose Phosphotransferase System Component IID Is a Novel RANK‐Binding Osteoclastogenic Factor

Advanced Science, EarlyView.
Streptococcal mannose phosphotransferase system component IID (Man‐PTSIID) is identified as a novel RANK‐binding osteoclastogenic factor. By directly binding to RANK and activating NF‐κB independently of TLR2, Man‐PTSIID drives osteoclastogenesis and inflammatory bone destruction, uncovering an unexpected microbial mechanism underlying streptococcal ...
Chaeyeon Park, Yeongkag Kwon, Yeonjin Lim, Jeong Woo Park, Hyun Jung Ji, Dongwook Lee, Jueun Lee, Sung‐Ho Yun, Sungho Jeong, Ho Seong Seo, Kun Cho, Cheol‐Heui Yun, Ok‐Jin Park, Seung Hyun Han   +13 more
wiley   +1 more source

Epidemiological and Clinical-Laboratorial Profile of Schistosomiasis in an Endemic Urban Area in Pernambuco, Brazil. [PDF]

Acta Parasitol
da Silva Pereira ME, Júnior WLB, da Silva Fernandes DLR, Domingues ALC, de Lorena VMB, de Souza Gomes EC.   +5 more
europepmc   +1 more source

O Fôro no Estado Novo

Revista da Faculdade de Direito, Universidade de São Paulo, 1940
openaire   +2 more sources

α‐Synuclein Forms Distinct Micelle‐Like Assemblies at Low Ionic Strengths

Advanced Science, EarlyView.
At high ionic strength, α‐synuclein forms diverse assemblies, including oligomers, fibrils, and condensates. Here, we show that at low ionic strength, α‐synuclein adopts a distinct, low‐abundance assembly state. These assemblies maintain a constant size above a critical concentration and do not coalesce, suggesting a micelle‐like organization ...
Sophie Hertel, Soumik Ray, Federica Saraceno, Giacomo Nisini, Georgia Nasi, Thomas Oliver Mason, Antonin Kunka, Effrosyni Agrimaki, Dannie Juul Olesen, Francesco Simone Ruggeri, Alexander K. Buell   +10 more
wiley   +1 more source

Tracking the Global Prevalence and Distribution of the AmpC-β-Lactamase-Carrying pESM Megaplasmid in <i>Salmonella</i> Minnesota. [PDF]

Genes (Basel)
Dos Santos AMP, Portes AB, Souza HCA, Panzenhagen P, Almeida ACO, Ferrari RG, Conte-Junior CA.   +6 more
europepmc   +1 more source