Results 221 to 230 of about 16,315 (293)

Estado Novo: ditadura civil-militar

Religación
  Este trabalho trata da ditadura imposta por Getúlio Vargas, presidente brasileiro desde a revolução de 1930, que com o auxílio dos militares instalou o Estado Novo (1937-1945). O período de 1930 a 1937 é bastante conturbado, havendo contado com greves operárias, a revolução de 1932, o levante de 1935, bem como com inúmeras manifestações populares e ...
openaire   +1 more source

Dynamic Regulation of Endogenous Transcription Factor Hubs at Single‐Molecule Resolution

Advanced Science, EarlyView.
This study combines single‐molecule microscopy and genome editing to characterize the dynamic behaviors of endogenous oncofusion transcription factor EWS::FLI1 in Ewing sarcoma cells. EWS::FLI1 forms neomorphic hubs that dynamically assemble and dissolve. The hubs are regulated during mitosis, by RNA, and by specific chemicals.
Shawn Yoshida, Yanghao Zhong, Akiko Kumagai, William G. Dunphy, Shasha Chong   +4 more
wiley   +1 more source

A giant virus in a small lake: characterization of a new tropical algal virus expands the geographical and genetic diversity of the Brazilian virosphere. [PDF]

J Virol
Filho CAdC, Canto ILdJ, Botelho BBF, Henriques LR, Carvalho JVRP, Oliveira EGd, Souza SAdC, Souza JW, Teixeira Lima M, Iani FCdM, Haisi A, Pessoa Araújo Júnior J, Rodrigues RAL.   +12 more
europepmc   +1 more source

Revisiting Target‐Aware de novo Molecular Generation with TarPass: Between Rational Design and Texas Sharpshooter

Advanced Science, EarlyView.
TarPass provides a rigorous benchmark for target‐aware de novo molecular generation by jointly evaluating protein‐ligand interactions, molecular plausibility, and drug‐likeness on 18 well‐studied targets. Results show that current models often fail to consistently surpass random baseline in target‐specific enrichment, while post hoc multi‐tier virtual ...
Rui Qin, Zijie Chen, Yurong Li, Meijing Fang, Longji Shen, Yilong Su, Odin Zhang, Qinghan Wang, Qun Su, Jike Wang, Tingjun Hou, Yu Kang   +11 more
wiley   +1 more source

An ultra-processed food-based cafeteria diet induces obesity, metabolic dysfunction, and tissue-specific gene dysregulation in C57BL/6 mice. [PDF]

Animal Model Exp Med
Duarte GCK, Crispim D, Wittée SC, Lemos JRN, Lemos NE, de Oliveira MS, Alves MD, Massignam ET, Assmann TS, Pellenz FM.   +9 more
europepmc   +1 more source

Biosynthesis of Sciadonic Acid Derived from Gymnosperms with Anti‐Colitis Activity

Advanced Science, EarlyView.
This study establishes an efficient Yarrowia lipolytica platform for unusual sciadonic acid (SCA) production and assess the anti‐colitis efficacy in mice of SCA, supporting its potential as a novel therapeutic lipid. ABSTRACT Sciadonic acid (SCA), Δ5‐unsaturated fatty acid with anti‐inflammatory and lipid‐regulatory properties, is predominantly derived
Yadi Gao, Wei Liu, Xiuping Liang, Jie Bai, Hong Chang, Wenchao Chen, Mohamed A. Farag, Jianbo Xiao, Huifeng Jiang, Jiasheng Wu, Lili Song   +10 more
wiley   +1 more source

Watermelon Nutritional Composition with a Focus on L-Citrulline and Its Cardioprotective Health Effects-A Narrative Review. [PDF]

Nutrients
Baião DDS, da Silva DVT, Paschoalin VMF.   +2 more
europepmc   +1 more source

GLS1 Orchestrates Exosome‐Mediated Tumor‐Endothelial Communication to Facilitate Angiogenesis

Advanced Science, EarlyView.
This study reveals a previously unappreciated, non‐metabolic function of GLS1 in the control of tumor angiogenesis via exosome‐mediated CAV1‐TNC signaling, indicating that therapeutic targeting of GLS1 may offer a dual benefit by simultaneously suppressing tumor metabolic activity and angiogenic processes in head and neck cancer. ABSTRACT Glutaminase 1
Jianqiang Yang, Zhenzhen Fu, Fanghui Chen, Soumya Vijaya Kumar, Fan Yang, Yaochao Zheng, Yunqi Li, Yao Yao, Nabil F. Saba, Yong Teng   +9 more
wiley   +1 more source

Perioperative screening and management of hyperglycemia: a joint position statement from the Brazilian Diabetes Society (SBD), the Brazilian Society of Anesthesiology (SBA) and the Brazilian Association for the Study of Obesity and Metabolic Syndrome (ABESO). [PDF]

Diabetol Metab Syndr
Marino EC, Negretto LAF, Ribeiro RS, Momesso D, Feitosa ACR, Toyoshima MTK, da Silva Junior JC, Vencio S, Lauria MW, de Sá JR, Malerbi DA, Valente F, Leite SAO, Amaral DEO, Guimarães GMN, da Cunha Leal P, Lopes MB, Salles LCB, de Araújo Azi LMT, Fonseca AG, Carvalho LIM, Coelho FF, Halpern B, Valerio CM, Trujilho FR, Brandão ACA, Lyra R, Bertoluci M.   +27 more
europepmc   +1 more source