Results 61 to 70 of about 1,021,999 (290)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Portaria de Credenciamento ENFAM n. 222 de 13 de agosto de 2015 [PDF]
, 2015 Credencia o curso "Sentença no Novo CPC" promovido pela Escola Superior da Magistratura do Estado da ...
Escola Nacional de Formação e Aperfeiçoamento de Magistrados (Brasil) (ENFAM)
core
FEBS Open Bio, EarlyView.We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley +1 more source
English-Language Books Censored during Wartime in Estado Novo Portugal [PDF]
, 2017 . In contrast to press censorship, books published in Estado Novo Portugal were not subject to a priori censorship, but rather post-publication censorship.
Gombár, Zsófia
core +2 more sources
The role of lipid metabolism in neuronal senescence
FEBS Open Bio, EarlyView.Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari +2 more
wiley +1 more source
Notas sobre a educação nacional na era getuliana
História da Educação, 2012 Com o objetivo de discutir questões relativas ao tema da educação nacional no Estado Novo (1937-1945), apresentam-se nestas notas resultados parciais da análise de três livros considerados representativos para a compreensão da problemática relativa à ...
Carlos Monarcha
doaj
FEBS Open Bio, EarlyView.Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source
The New Developmentalism and Conventional Orthodoxy [PDF]
O Fracasso das Políticas e Reformas Propostas por Washington e Nova York, Aqui Denominadas Ortodoxia Convencional , em Promover a Estabilização e o Crescimento Econômico na América Latina Abriu Espaço para o Surgimento de uma Estratégia Nacional de ...
Pereira, Luiz Carlos Bresser
core