Results 61 to 70 of about 1,021,196 (293)

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

Portaria de Credenciamento ENFAM n. 222 de 13 de agosto de 2015 [PDF]

open access: yes, 2015
Credencia o curso "Sentença no Novo CPC" promovido pela Escola Superior da Magistratura do Estado da ...
Escola Nacional de Formação e Aperfeiçoamento de Magistrados (Brasil) (ENFAM)
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

The New Developmentalism and Conventional Orthodoxy [PDF]

open access: yes
O Fracasso das Políticas e Reformas Propostas por Washington e Nova York, Aqui Denominadas Ortodoxia Convencional , em Promover a Estabilização e o Crescimento Econômico na América Latina Abriu Espaço para o Surgimento de uma Estratégia Nacional de ...
Pereira, Luiz Carlos Bresser
core  

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

open access: yesFEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini   +2 more
wiley   +1 more source

Notas sobre a educação nacional na era getuliana

open access: yesHistória da Educação, 2012
 Com o objetivo de discutir questões relativas ao tema da educação nacional no Estado Novo (1937-1945), apresentam-se nestas notas resultados parciais da análise de três livros considerados representativos para a compreensão da problemática relativa à ...
Carlos Monarcha
doaj  

Evolutionary dynamics of the chloroplast genome in Daphne (Thymelaeaceae): comparative analysis with related genera and insights into phylogenetics

open access: yesFEBS Open Bio, EarlyView.
Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah   +8 more
wiley   +1 more source

Construindo um novo espaço urbano no Estado Novo:

open access: yesFaces de Clio, 2019
As empresas cariocas da indústria da construção civil ao longo do Estado Novo (1937-1945) constituem o objeto de estudo deste trabalho. Examinaremos o estágio de desenvolvimento do setor neste período e as principais políticas da gestão do prefeito Henrique Dodsworth para o setor.
openaire   +2 more sources

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

open access: yesFEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang   +7 more
wiley   +1 more source

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