Results 91 to 100 of about 45,405 (265)
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Telos: Revista de Estudios Interdisciplinarios en Ciencias Sociales, 2006 Este estudio presenta un análisis sobre las versiones jurisprudenciales que irradian en Venezuela el esquema de Libertad Económica, así como también la libertad de trabajo consagrado en la Constitución de la República Bolivariana de Venezuela ...
Julio César Álvarez
doaj
Human dignity and social rights
Ars Iuris Salmanticensis, 2020 This article analyzes the legal concept of human dignity, starting from its moral, ethical notion. Dignity is the source and origin of all human rights, it is a special quality that corresponds to each person and therefore it must always be linked to the
María Josefa GARCÍA-MAESTRO GARCÍA
doaj
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
, 2016 Este trabajo se asienta sobre dos ejes, por un lado el carácter social de nuestro Estado y por otro lado su organización territorial autonómica. Para referirnos al primero nos sirve como referencia el articulo 1 de nuestra Constitución que califica al Estado como social, democrático y de derecho.
openaire +2 more sources
Estado democrático y social de derecho.
Boletín Mexicano de Derecho Comparado, 2000 ESTADO DEMOCRÁTICO Y SOCIAL DE DERECHO Sergio GARCÍA RAMÍREZ ¿Existe un solo Estado democrático y social de derecho? Si no lo hay, ¿cuáles son los tipos admisibles, sin caer en la dispersión, la dilusión del concepto, que a fuerza de decir muchas cosas acabe por no decir ninguna?
openaire +4 more sources
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Vulnerabilidad. Reducto o frontera del Estado social
Revista de Derecho PúblicoEl concepto de vulnerabilidad es utilizado cada vez con más frecuencia en el ordenamiento jurídico interno e internacional tanto en normas de Derecho público, como de Derecho privado. A pesar de su auge y naturalización", lo cierto es que es un concepto
Alba Nogueira López
doaj +1 more source
Estado social e princípio da solidariedade
Revista de Direitos e Garantias Fundamentais, 2008 O presente trabalho analisa o tema da solidariedade a partir de uma evolução histórica, buscando revelar a sua importância na construção do ideal de solidariedade e bem comum. Tais elementos são centrais na perspectiva da ética, na medida em que o indivíduo ético, consciente também reconhece a autonomia e a diferença, próprias de cada um.
openaire +2 more sources
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source