Results 171 to 180 of about 48,696 (263)

Burden and Patterns of Oral Diseases and Systemic Comorbidities in Older Adults Attending Primary Care: A Sex- and Age-Stratified Analysis. [PDF]

Medicina (Kaunas)
Lopez-Hernandez D, Sanchez-Hernandez OE, Anguiano-Velazquez TG, Brito-Aranda L, Carrera-Vite AV, Izquierdo-Vega AJ, Salinas-Palacios PV, Reynoso-Vazquez J, Espinoza-Perdomo A, Crisantos-Reyes NE, Sevilla-Mendoza CD, Gonzalez-Sandoval MA, Meneses-Mayo M, Salazar-Campos A.   +13 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Climate change and mental health: an urgent call for strategic action from nursing. [PDF]

Rev Bras Enferm
Ribeiro ÍAP, Moraes Filho IM, Oliveira ALCB, Lira Neto JCG, Tavares GG, Fernandes MA.   +5 more
europepmc   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Anxiety in mothers of children with COVID-19 based on the State-Trait Anxiety Inventory. [PDF]

Rev Bras Enferm
Fontenele NL, Santos DAS, Castro IAL, Paiva FM, Fontoura FC, Oliveira NR, Oliveira RKL, Cardoso MVLML.   +7 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

REGULACIÓN CONSTITUCIONAL Y POSIBILIDAD DEL ESTADO SOCIAL

Revista Vasca de Administración Pública, 1988
Miguel Ángel García Herrera, Gonzalo Maestro Buelga   +1 more
doaj   +1 more source

Unidentified women in emergency services: care provided in public hospital emergency services. [PDF]

Rev Bras Enferm
Sousa FCP, Santos FO, Curityba GM, Fonseca CN, Silva AGD, Corrêa ADR.   +5 more
europepmc   +1 more source

Política social comunitaria y estado de bienestar.

, 1993
ESP
openaire   +3 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source