Results 151 to 160 of about 270,121 (304)
Plan de mejora de la formación de los estudiantes de enfermería sobre el paciente en estado terminal
, 2021 Introducción: la sedación y los cuidados paliativos son la consecuencia de un aumento en la esperanza de vida y de las enfermedades crónicas. Esta realidad ha contribuido a valorar la calidad de la formación que reciben los estudiantes de enfermería, la cual, es imprescindible para manejar los aspectos claves del cuidado del enfermo terminal. Objetivo:
Baciu, Andra Costina +1 more
openaire +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Revista de Estudos Sociais, 2015 O presente artigo visa avaliar os impactos da implantação do terminal intermodal da Ferronorte que liga Santa Fé do Sul, em São Paulo a Rondonópolis, no sudeste de Mato Grosso.
Luís Otávio Bau Macedo +3 more
doaj
, 2011 A vivência de uma doença ameaçadora de vida, como é exemplo o cancro, é reconhecida como uma situação geradora de desadaptação não apenas para o doente mas também para os seus cuidadores, que partilham com ele o sofrimento e o distress psicológico associado (Kissane, Bloch, Burns, McKenzie e Posterino, 1994). Outro dos factores que pode ser considerado
Moutinho, S., Lima, Ligia
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Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Revista Cubana de Estomatología, 2005 La miasis son infestaciones de vertebrados vivos por larvas de moscas que se nutren como parásitos. Frecuentemente, la miasis está relacionada con la pobreza extrema y la falta de higiene en países en desarrollo con climas calientes y húmedos. En esas circunstancias especificas, heridas abiertas y no tratadas, úlceras, tejidos necróticos y todos los ...
Marconi Eduardo Sousa Maciel-Santos +3 more
openaire +1 more source