Results 131 to 140 of about 16,606 (215)

Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown, Giulia Carli, Prabesh Kanel, Stiven Roytman, Jaimie Barr, Nicolaas I. Bohnen, Roger L. Albin   +6 more
wiley   +1 more source

Vascular access in Pará: clinical and epidemiological aspects of patients on renal replacement therapy at the largest specialist center in Pará state, Brazil. [PDF]

J Vasc Bras
Dos Reis JMC, Silva IB, Monteiro MGPB, Guerra MMNB, da Costa DL, Rodrigues FFP, de Andrade MC.   +6 more
europepmc   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Pioneering Investigation on the Larvicidal Mechanism and Chemical Profile of <i>Piper humillimum</i> C.DC. (Piperaceae) Essential Oil: Integrating <i>In Vivo</i>, <i>In Vitro</i>, and <i>In Silico</i> Models Against <i>Aedes aegypti</i> (Linnaeus, 1762) and <i>Anopheles darlingi</i> Root, 1926 (Culicidae). [PDF]

Molecules
de Oliveira AC, da Costa MLL, Marcusso GM, Simões RC, Serrão RNG, Figueira ÉAG, de Lima GS, Vasconcelos ADS, Marques JA, Koolen HHF, da Silva FMA, Sá ISC, Nunomura RCS, Nunomura SM, Roque RA.   +14 more
europepmc   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

A Degradomic Landscape of Proteolytic Remodeling in Melanoma Lung Metastasis. [PDF]

J Proteome Res
Alves Martins Nogueira CE, Olímpio F, Salardani M, Barcick U, Fonseca LR, Aimbire F, Lima Jedlicka LD, Loures FV, Capelo LP, Lima V, Monteiro de Oliveira T, Barros BCSC, Serrano SMT, Zelanis A.   +13 more
europepmc   +1 more source

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source

First isolation of nontoxigenic tox gene-bearing Corynebacterium ulcerans from a diphtheria case in Minas Gerais, Brazil. [PDF]

Braz J Microbiol
Couto Calazans Silva A, de Oliveira Sant'Anna L, Nunes Soares PC, do Carmo Sant'Anna Cardoso T, Nunes Ramos J, Mattos-Guaraldi AL, Sanches Dos Santos L.   +6 more
europepmc   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Advances in the Use of Recombinant Gonadotropins for Reproductive Biotechnologies in Ruminants: A Review. [PDF]

Reprod Domest Anim
Di Domenico VL, de Moraes FP, de Castro NÁ, de Oliveira FC, Magnabosco D, Gasperin BG.   +5 more
europepmc   +1 more source