Results 131 to 140 of about 4,882,386 (282)
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Bioderecho.es, 2018 El dolor es una sensación, una experiencia personal desagradable, un síntoma que nos alerta del posible mal funcionamiento de nuestro organismo. El dolor es siempre subjetivo, muchas personas se quejan de dolores en ausencia de una causa fisiopatológica ...
Ana Belen Sánchez-Garcia +4 more
doaj
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
El adolescente ante la enfermedad terminal y la muerte
Revista de la Facultad de Ciencias de la Salud, 1999 El interés de la psicología, la psiquiatría y otras áreas de la salud por la muerte y el enfermo terminal se ha desarrollado apenas en los últimos años, a pesar de que la muerte constituye un fenómeno universal que ha estado presente durante toda la ...
María del Pilar Restrepo de Paz
doaj
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Revista de Estudos Sociais, 2015 O presente artigo visa avaliar os impactos da implantação do terminal intermodal da Ferronorte que liga Santa Fé do Sul, em São Paulo a Rondonópolis, no sudeste de Mato Grosso.
Luís Otávio Bau Macedo +3 more
doaj
Revista Cubana de Estomatología, 2005 La miasis son infestaciones de vertebrados vivos por larvas de moscas que se nutren como parásitos. Frecuentemente, la miasis está relacionada con la pobreza extrema y la falta de higiene en países en desarrollo con climas calientes y húmedos. En esas circunstancias especificas, heridas abiertas y no tratadas, úlceras, tejidos necróticos y todos los ...
Marconi Eduardo Sousa Maciel-Santos +3 more
openaire +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source