Results 151 to 160 of about 4,882,386 (282)

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Novel germline GATA1s-generating variant associates with somatic STAG2 variants in hypoplastic myelodysplastic neoplasm. [PDF]

Br J Haematol
Donaires FS, Catto LFB, Pinto AL, Tellechea MF, Catto MB, Molfetta GA, Santana BA, Traina F, Chahud F, Cle DV, Gutierrez-Rodrigues F, Calado RT.   +11 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Intestinal Ischemia Secondary to Ladd's Bands Obstruction Associated With Intestinal Malrotation in a One-Year-Old Pediatric Patient: A Case Report. [PDF]

Cureus
Moya-Leal B, Rodríguez-Garza M, Nava Palomo CL, Arzamendi A, Valdez-Cruz JL.   +4 more
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Structural Insights Into the Function of Leishmania major Adenylosuccinate Lyase. [PDF]

Proteins
E Silva IR, Mantovani M, Lino MESD, Albuquerque AO, da Silva JHM, Nagem RAP, Rojas AL, Sartori GR, Horjales E, Campbell D, Thiemann OH.   +10 more
europepmc   +1 more source

Pacto de silencio: perspectivas culturales de la revelación de la verdad al paciente en estado terminal

, 2016
Objective: To evaluate the possible influence of culture in relation to the presence of the pact of silence of terminally ill patients in today’s society. Methods: a narrative review has been done through bibliographic research in Health Science databases (Cochrane Plus, PubMed, Cinahl, SCielo, PsycINFO and EBSCO Host), scientific magazines and ...
Cordero Pulido, Esther, Palomar Catena, Laura   +1 more
openaire   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

An open-source code to analyze mitochondrial intracellular distribution from fluorescence microscopy images. [PDF]

Biosci Rep
Cavalcante GC, Kowaltowski AJ.
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source