Results 171 to 180 of about 270,121 (304)

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Diffusion Dynamics of Volatile Organic Compounds into Integrated Surface-Supported Metal-Organic Frameworks Heterojunctions. [PDF]

ACS Appl Mater Interfaces
Cescon Dos Santos T, Rodrigues de Araujo WW, Parra Vello T, Santos Batista CV, Albano LGS, Bufon CCB.   +5 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Exceptional Visual-Opsin Coexpression and Phenotypic Diversity in Outer-Retinal Photoreceptors of Caenophidian Snakes. [PDF]

J Comp Neurol
Hauzman E, Haverkamp S, Tashiro JH, Gügel IL, Torello-Viera NF, Guedes TB, Němec P, Casewell NR, Modahl CM, Oliveira ME, Prudente ALC, Mesquita DO, Ventura DF, Gower DJ.   +13 more
europepmc   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Design of Hybrid Bioactive Peptides Derived From Cecropin and Cathepsin for Therapeutic Application. [PDF]

Chem Biol Drug Des
Cepinho GS, Scavassa BV, de Cena GL, de Andrade VM, Lima LRF, Zelanis A, Heras M, Castanho MARB, Conceição K.   +8 more
europepmc   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Nanopore Size-Dependent Raman Spectroscopy of Two-Dimensional γ‑Graphyne. [PDF]

ACS Omega
de Almeida Garcia JM, Late DJ, Pimenta MA, Ribeiro-Soares J, Longuinhos Monteiro Lobato R.   +4 more
europepmc   +1 more source

A new access channel and turning basin for the Port of Lomé (Togo): from Design guidelines to simulator training [PDF]

, 2015
Candries, Maxim, Couvreur, Stijn, Eloot, Katrien, Peire, Kenneth, Vantorre, Marc, Vos, Stijn   +5 more
core   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source