BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma
FEBS Open Bio, EarlyView.The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru +6 more
wiley +1 more source
, 2016 Objective: To evaluate the possible influence of culture in relation to the presence of the pact of silence of terminally ill patients in today’s society. Methods: a narrative review has been done through bibliographic research in Health Science databases (Cochrane Plus, PubMed, Cinahl, SCielo, PsycINFO and EBSCO Host), scientific magazines and ...
Cordero Pulido, Esther +1 more
openaire +1 more source
Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes
FEBS Open Bio, EarlyView.We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde +3 more
wiley +1 more source
Preferential Solvation by Trifluoroethanol Drives α-Helical Folding in the Disordered S2 Region of the Escargot Protein. [PDF]
ChemphyschemPiccoli V +5 more
europepmc +1 more source
A Flexible Corporation: Classic Period House Societies in Eastern Mesoamerica
, 2001 House society models, based on the work of Levi-Strauss but since refined by cultural anthropologists and archaeologists, provide a good model for understanding social organization among the ancient Maya and their neighbors in Mesoamerica based on a ...
Hendon, Julia A., Joyce, Rosemary A.
core
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
Self-Assembly and Gelation Behavior of Methacrylated PEO-PPO-PEO Triblock Copolymer Pluronic F127. [PDF]
LangmuirBomediano MP +3 more
europepmc +1 more source
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
A Hydrolase-Rich Venom Beyond Neurotoxins: Integrative Functional Proteomic and Immunoreactivity Analyses Reveal Novel Peptides in the Amazonian Scorpion <i>Brotheas amazonicus</i>. [PDF]
Int J Mol SciWiezel GA +6 more
europepmc +1 more source