Results 101 to 110 of about 678,509 (260)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Revista Educação e Políticas em Debate, 2015 Este artigo analisou as legislações e os Projetos de Lei de diferentes Estados do Brasil que buscam garantir o direito à educação para as crianças e adolescentes hospitalizados e aqueles que precisam de Atendimento Pedagógico em Ambiente Domiciliar.
Ercília Maria Angeli Teixeira de Paula +2 more
doaj +2 more sources
Carolina Calvache Cuarteto, jazz (Colombia / Estados Unidos)
, 2018 El cuarteto de Carolina Calvache ha llevado su música a importantes escenarios de Nueva York, Texas y Washington D.C. (Estados Unidos), tales como Jazz at Lincoln Center, el Jazz Gallery y el Vermont Jazz Center, con presentaciones que dan cuenta de la ...
Juanita Calvache Cuarteto - Jazz (Colombia / Estados Unidos)
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Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Cuarteto Prism, cuarteto de saxofones (Estados Unidos)
, 2019 Cuarteto Prism, cuarteto de saxofones Programas intrigantes de enorme belleza y envergadura han servido para destacar al Cuarteto Prism como uno de los principales ensambles de música de cámara en los Estados Unidos.
Cuarteto Prism - Cuarteto de saxofones (Estados Unidos)
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Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Cuarteto Emerson, cuarteto de cuerdas (Estados Unidos)
, 2017 Concierto interpretado por Cuarteto Emerson. Conformado en 1976 y con sede en la ciudad de Nueva York, el Cuarteto de Cuerdas Emerson, que tomó su nombre del poeta y filósofo norteamericano Ralph Waldo Emerson, fue uno de los primeros cuyos violinistas ...
Cuarteto Emerson - Cuarteto de cuerdas (Estados Unidos)
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Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source