Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Challenges for health systems in Latin America: far beyond emergencies. [PDF]
Cad Saude PublicaMachado CV, Uribe-Gómez M, Hein AA.
europepmc +1 more source
Los Estados de Excepción en el Ordenamiento Jurídico Venezolano
, 2018 El presente trabajo aborda un tema muy importante en el Derecho Constitucional de cualquier país, máxime al ser regulado en forma novedosa en la Constitución de 1999, y fue presentado para ascender a la categoría de Profesora Agregada, en la cátedra de ...
Peña Colmenares, Nélida Rosanna
core
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
[Expansion of the use of technologies to reduce cases of malaria due to Plasmodium vivax in the Brazilian Amazon: a budget impact analysis]. [PDF]
Cad Saude PublicaCosta MGSD +4 more
europepmc +1 more source
Cuarteto Calder, cuarteto de cuerdas (Estados Unidos)
, 2012 Concierto interpretado por el Cuarteto Calder. Este grupo desafía las fronteras de la música con sus interpretaciones de gran calidad abarcando n vasto repertorio que siempre trata de transmitir la intención real del compositor.
Cuarteto Calder - Cuarteto de cuerdas (Estados Unidos)
core
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
[Commercially available complementary foods in Argentina and Mexico: An analysis of their nutritional composition, labeling, and promotionAlimentos complementares comercializados na Argentina e no México: análise da composição nutricional, rotulagem e promoção]. [PDF]
Rev Panam Salud PublicaZapata ME +7 more
europepmc +1 more source
David Shifrin, clarinete (Estados Unidos) y Yevgeny Yontov, piano (Israel)
, 2013 Concierto interpretado por David Shifrin y Yevgeny Yontov acompañado en el piano de Christopher Jepperson. David reconocido solista orquestal, recitalista y músico de cámara, ganador del Premio Avery Fisher, se ha presentado como solista con las ...
Shifrin, David - Clarinete (Estados Unidos); Yontov, Yevgeny - Piano (Israel)
core
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source