Results 181 to 190 of about 192,226 (349)

Intranasal diamorphine population pharmacokinetics modeling and simulation in pediatric breakthrough pain

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 435-447, March 2025.
Abstract Intranasal diamorphine (IND), approved for managing breakthrough pain in the UK, has been identified as an acceptable alternative offering effective, expedient, and less traumatic analgesia for children. However, the current dose regimen in pediatric populations relies on clinical expertise while the pharmacokinetics properties are poorly ...
Lianjin Cai, Jingchen Zhai, Beihong Ji, Fengyang Han, Taoyu Niu, Luxuan Wang, Junmei Wang   +6 more
wiley   +1 more source

Emerging Approaches for Phytoconstituent Delivery in the Management of Rheumatoid Arthritis: Bridging Nature and Nanotechnology

Phytotherapy Research, EarlyView.
ABSTRACT Rheumatoid arthritis (RA) is an autoimmune condition marked by joint inflammation, cartilage destruction, and bone damage. Conventional treatments, including NSAIDs and DMARDs, have shown effectiveness in slowing down disease progression, but prolonged exposure to such medications results in adverse effects and lack of tolerance among patients.
Yogesh Khairnar, Sakshi Priya, Madhavi Rajpara, Venkatesh K. P. Rao, Geeta Bhatt, Gautam Singhvi   +5 more
wiley   +1 more source

The Effect of Natural Compounds on Cognitive Impairment Through BDNF/TrkB/CREB Pathway: A Review

Phytotherapy Research, EarlyView.
Natural compounds improve cognitive function by activating BDNF/TrkB/CREB signaling to reduce neuroinflammation, oxidative stress, apoptosis, and Aβ accumulation while promoting synaptogenesis. ABSTRACT Considering the global prevalence of Alzheimer's disease (AD) and the restrictions of current treatment procedures, natural compounds (such as curcumin,
Vahid Pourbarkhordar, Sohrab Rahmani, Hossein Hosseinzadeh, Soghra Mehri   +3 more
wiley   +1 more source

A Cytoplasmic pH Sensor Redefines Gating in Bacterial Urea Channels and Acid Resistance

Small, EarlyView.
Bacterial survival in acidic environments requires pH‐gated urea channels. Utilizing complementary approaches, we identify a conserved cytoplasmic glutamic acid residue as a pH sensor in UreI channels. Whereas Gram‐positive bacteria rely solely on this sensor, Gram‐negative bacteria employ a dual‐sensor mechanism with periplasmic residues, revealing a ...
Anna Stoib, Sahar Shojaei, Xenia Fischer, Sandra Posch, Gianluca Parisse, Mario Frezzini, Tobias Putz, Christine Siligan, Nikolaus Goessweiner‐Mohr, Daniele Narzi, Andreas Horner   +10 more
wiley   +1 more source

Design, synthesis and activity evaluation of tetrahydroisoquinoline‐based programmed cell death ligand 1 inhibitors

Smart Molecules, EarlyView.
Based on a 3D‐quantitative structure‐activity relationship pharmacophore model, structural optimization of Y6 yielded Y7f. Mechanistic studies revealed that Y7f acted as a programmed death receptor 1/programmed cell death ligand 1 (PD‐L1) interaction inhibitor by inducing PD‐L1 dimerization. Y7f restored T‐cell function.
Menglin Yu, Sen Cai, Yanyan Pan, Heshuang Wang, Fengwu Zhang, Aiyu Ma, Shixuan Lv, Xiuhan Guo, Shisheng Wang, Qiling Song, Chunyan Ma, Shuai Wang, Li Zhang, Jian Wang, Qingwei Meng, Yueqing Li   +15 more
wiley   +1 more source

The Alpha-Defensin Immunoassay and Leukocyte Esterase Colorimetric Strip Test for the Diagnosis of Periprosthetic Infection: A Systematic Review and Meta-Analysis.

Journal of Bone and Joint Surgery. American volume, 2016
M. Wyatt, A. Beswick, S. Kunutsor, Matthew Wilson, M. Whitehouse, A. Blom   +5 more
semanticscholar   +1 more source

Stimuli‐responsive nanostructured hydrogen sulfide donors for enhanced cancer treatments

Smart Molecules, EarlyView.
Three typical kinds of stimuli‐responsive nanostructured hydrogen sulfide (H2S) donors are reviewed. The nanostructures ensure precise delivery of H2S to the lesion site and regulate the release behavior. The H2S‐based gas therapy has been used to synergize with other cancer treatment modalities, achieving enhanced efficacy while reducing side effects.
Yuxuan Lyu, Jiaxuan Zhu, Lei Lei, Qingyang Zhong, Zhao Li, Caihong Lei, Fan Rong, Yin Wang   +7 more
wiley   +1 more source

Rational design of a lipophilic β‐galactosidase‐responsive near‐infrared probe for in vivo imaging of cellular senescence

Smart Molecules, EarlyView.
We developed a lipophilic near‑infrared probe (DCIP‑AcGal) that is specifically activated by senescence‑associated β‑galactosidase. After intravenous injection, it lights up therapy‑induced tumor senescence in living mice. Its optimized lipophilicity also enables blood‑brain barrier crossing to detect natural brain senescence ex vivo. This probe offers
Jiani Huang, Feiyi Chu, Bin Feng, Lin Chen, Peili Cen, Jing Wang, Ying Qu, Lu Hong, Fei Wu, Huanfeng Tian, Yanpeng Fang, Yuanjie Chen, Mei Tian, Wenbin Zeng, Hong Zhang, Yan Zhong   +15 more
wiley   +1 more source

Fragment-based active-site exploration of urethane hydrolases reveals a diversity of urethane binding modes. [PDF]

Acta Crystallogr D Struct Biol
Bicer D, Kochubei D, Graham R, Peña-Díaz S, Rotilio L, Villadsen NL, Sommerfeldt A, Johansen MB, Sandahl A, Thirup SS, Morth JP, Otzen DE.   +11 more
europepmc   +1 more source

Conquering the stronghold: Membrane‐targeting anti‐infective drug discovery

Smart Molecules, EarlyView.
This perspective elucidates how XM‐01 and BLA combat infections through modulating pathogen membranes, disrupting biological processes, and potentiating therapeutics, offering cutting‐edge insights into anti‐infective drug mechanisms, innovations, and clinical translation.
Yanxu Hou, Jiwei Zhang, Bing Huang, Peng Zhan, Xinyong Liu   +4 more
wiley   +1 more source