Results 181 to 190 of about 124,633 (302)

Investigation of atypical microbial agents in patients with sterile pyuria. [PDF]

open access: yesAnn Clin Microbiol Antimicrob
Tanrıverdi ES   +3 more
europepmc   +1 more source

The Crystallization of Liver Esterase. [PDF]

open access: yesActa Chemica Scandinavica, 1948
M. Safwat Mohamed   +2 more
openaire   +2 more sources

Design, synthesis and activity evaluation of tetrahydroisoquinoline‐based programmed cell death ligand 1 inhibitors

open access: yesSmart Molecules, EarlyView.
Based on a 3D‐quantitative structure‐activity relationship pharmacophore model, structural optimization of Y6 yielded Y7f. Mechanistic studies revealed that Y7f acted as a programmed death receptor 1/programmed cell death ligand 1 (PD‐L1) interaction inhibitor by inducing PD‐L1 dimerization. Y7f restored T‐cell function.
Menglin Yu   +15 more
wiley   +1 more source

Stimuli‐responsive nanostructured hydrogen sulfide donors for enhanced cancer treatments

open access: yesSmart Molecules, EarlyView.
Three typical kinds of stimuli‐responsive nanostructured hydrogen sulfide (H2S) donors are reviewed. The nanostructures ensure precise delivery of H2S to the lesion site and regulate the release behavior. The H2S‐based gas therapy has been used to synergize with other cancer treatment modalities, achieving enhanced efficacy while reducing side effects.
Yuxuan Lyu   +7 more
wiley   +1 more source

Rational design of a lipophilic β‐galactosidase‐responsive near‐infrared probe for in vivo imaging of cellular senescence

open access: yesSmart Molecules, EarlyView.
We developed a lipophilic near‑infrared probe (DCIP‑AcGal) that is specifically activated by senescence‑associated β‑galactosidase. After intravenous injection, it lights up therapy‑induced tumor senescence in living mice. Its optimized lipophilicity also enables blood‑brain barrier crossing to detect natural brain senescence ex vivo. This probe offers
Jiani Huang   +15 more
wiley   +1 more source

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