Results 71 to 80 of about 2,367,461 (269)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Alcoholic Liver Disease/Nonalcoholic Fatty Liver Disease Index at Diagnosis Is Associated with All-Cause Mortality during Follow-Up in Patients with Antineutrophil Cytoplasmic Antibody-Associated Vasculitis

Medicina
Background and Objectives: The purpose of this study was to investigate whether a new index related to chronic liver disease, the alcoholic liver disease/nonalcoholic fatty liver disease index (ANI) at diagnosis, is associated with all-cause mortality ...
Minsuk Cho, Woongchan Rah, Jason Jungsik Song, Yong-Beom Park, Sang-Won Lee   +4 more
doaj   +1 more source

Measurement and estimation of the angle of attack and the angle of sideslip

Aviation, 2015
The paper presents issues concerning the estimation of the angle of attack and the angle of sideslip on a flying object board. Angle of attack and sideslip estimation methods which are based on measurements of linear velocity components of an object with
Stanisław Popowski, Witold Dąbrowski
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The raise estimator estimation, inference, and properties

Communications in Statistics - Theory and Methods, 2017
Several methods using different approaches have been developed to remedy the consequences of collinearity. To the best of our knowledge, only the raise estimator proposed by García et al. (Citation2010) deals with this problem from a geometric perspective.
Salmerón Gómez, Román, García García, Catalina, García Pérez, José, López Martín, María Del Mar   +3 more
openaire   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Study on the population structure of the paradoxical frog, Pseudis bolbodactyla (Amphibia: Anura: Hylidae), using natural markings for individual identification

Zoologia (Curitiba), 2013
The goal of this study was to assess the population structure of Pseudis bolbodactyla Lutz, 1925 using natural markings to identify individuals. Recruitment, survival, and population size estimations were obtained using the Jolly-Seber stochastic method.
Werther P. Ramalho, Rafael F. Jorge, Leandro B. Baiocchi, Alfredo P. Peña, Ricardo A. P. Pires   +4 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

BAYES RISKS OF ESTIMATORS OF ESTIMABLE PARAMETERS [PDF]

Bulletin of Mathematical Statistics, 1980
For the estimable parameter of degree 2, throughout this paper, we consider 02 with h2 such that h2(x, x) and h2(x, x)=0 for any x, yEX. As estimators of estimable parameters, U-statistics and differentiable statistical functions are well known. (See, for example, Hoeffding (1948) and von Mises (1947).) For an estimable parameter of degree 1, the U ...
openaire   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source