Results 101 to 110 of about 279,299 (375)

Polymorphisms in the heme oxygenase-1 and bone morphogenetic protein receptor type 1b genes and estimated glomerular filtration rate in Brazilian sickle cell anemia patients

Hematology, Transfusion and Cell Therapy, 2021
Introduction: Mutations affecting genes involved in oxidative and signaling pathways may be associated with kidney disease in sickle cell anemia. We determined the allele and genotype frequencies of some polymorphisms in the promoter regions of the Heme ...
Okeke Chinedu, Wouitchékpo Vincent Tonassé, Dulcinéia Martins Albuquerque, Igor de Farias Domingos, Aderson da Silva Araújo, Marcos André Cavalcanti Bezerra, Maria de Fátima Sonati, Magnun Nueldo Nunes dos Santos   +7 more
doaj  

Cystatin C as Biomarker for the Evaluation of Renal Outcome in AL Amyloidosis

American Journal of Hematology, EarlyView.
ABSTRACT Cystatin C (CysC) has emerged as a novel and potentially more reliable biomarker for the estimation of glomerular filtration in the general population in patients with various conditions. In AL amyloidosis, the current renal staging system and renal response criteria are based on proteinuria and creatinine‐based eGFR.
Foteini Theodorakakou, Despina Fotiou, Filia Apostolakou, Ioannis Papassotiriou, Vasiliki Spiliopoulou, Ioannis Ntanasis‐Stathopoulos, Panagiotis Malandrakis, Magdalini Migkou, Nikolaos Kanellias, Evangelos Eleutherakis‐Papaiakovou, Erasmia Psimenou, Asimina Papanikolaou, Charikleia Gakiopoulou, Smaragdi Marinaki, Stavroula Giannouli, Maria Gavriatopoulou, Evangelos Terpos, Meletios‐Athanasios Dimopoulos, Efstathios Kastritis   +18 more
wiley   +1 more source

Relationship of coffee consumption with a decline in kidney function among patients with type 2 diabetes: The Fukuoka Diabetes Registry

Journal of Diabetes Investigation, 2022
Aims/Introduction The evidence regarding the effects of coffee consumption on incident chronic kidney disease is inconclusive, and no studies have investigated the relationship in patients with diabetes.
Yuji Komorita, Toshiaki Ohkuma, Masanori Iwase, Hiroki Fujii, Hitoshi Ide, Yutaro Oku, Taiki Higashi, Ayaka Oshiro, Wakako Sakamoto, Masahito Yoshinari, Udai Nakamura, Takanari Kitazono   +11 more
doaj   +1 more source

The Impact of Reporting Estimated Glomerular Filtration Rate

Renal Failure, 2011
The 'Kidney Disease Outcomes Quality Initiative' guidelines recommend laboratory reporting of a calculated estimated glomerular filtration rate (eGFR). The United Kingdom and several states already mandate reporting eGFR for every laboratory serum creatinine (sCr) measurement. In our study, we evaluated the impact of reporting eGFR on the management of
Claude Bassil, Marie Abdallah, Nadine Azzi, Ayesha Siddiqui, Pratima Ghimire, Suzanne El-Sayegh, Abdallah S. Geara   +6 more
openaire   +3 more sources

Refining the adriamycin‐induced focal segmental glomerulosclerosis mouse model to improve reproducibility and animal welfare

Animal Models and Experimental Medicine, EarlyView.
This study suggested the instability of Adriamycin (ADR) in aqueous solution as the main contributor to large ADR dose variations in literature of the ADR‐induced mouse model of focal segmental glomerulosclerosis (FSGS). We confirmed that freshly prepared ADR solution dosed at 10.5 mg/kg to be optimal in reliably producing FSGS pathology in BALB/c mice
Haochen Jiang, Salma Althobaiti, Braeden Pinkerton, Xin Fu, Zhenshan Jia, Kirk W. Foster, Geoffrey M. Thiele, Troy J. Plumb, Dong Wang   +8 more
wiley   +1 more source

Alterations to peritubular capillary structure in a rat model of kidney interstitial fibrosis: Implications for oxygen diffusion

The Anatomical Record, Volume 308, Issue 5, Page 1492-1503, May 2025.
Abstract Fibrosis and loss of functional capillary surface area may contribute to renal tissue hypoxia in a range of kidney diseases. However, there is limited quantitative information on the impact of kidney disease on the barriers to oxygen diffusion from cortical peritubular capillaries (PTCs) to kidney epithelial tubules.
Sarah E. Gazzard, Luise A. Cullen‐McEwen, Marina Nikulina, Arnold B. Clever, Bruce S. Gardiner, David W. Smith, Chang‐Joon Lee, Jens R. Nyengaard, Roger G. Evans, John F. Bertram   +9 more
wiley   +1 more source

Postnatal maturation of the glomerular filtration rate in conventional growing piglets as potential juvenile animal model for preclinical pharmaceutical research [PDF]

, 2017
Adequate animal models are required to study the preclinical pharmacokinetics (PK), pharmacodynamics (PD) and safety of drugs in the pediatric subpopulation.
Croubels, Siska, Delanghe, Joris, Devreese, Mathias, Gasthuys, Elke, Heyndrickx, Marjolein, Millecam, Joske, Sys, Stanislas, Vande Walle, Johan, Vanderperren, Katrien   +8 more
core   +3 more sources

Determination of selenium speciation in the muscle, kidney, and liver from different animals treated with different selenium supplements by HPLC‐ICP‐MS

Animal Research and One Health, EarlyView.
Dietary selenium (Se) deficiency is recognized as a global problem, and exogenous Se supplementation can effectively enrich its levels in animal bodies. Offal tissues are equally important as meat in Se enrichment. Varying properties among Se species require information beyond total Se concentration to fully evaluate health risk/benefits.
Xiaoqing Guo, Xueting Jia, Kai Zhang, Chaohua Tang, Xueyang Si, Bo He, Manus Carey, Lynda S. Perkins, Qingyu Zhao, Junmin Zhang   +9 more
wiley   +1 more source

Association between circulating tumor necrosis factor-related biomarkers and estimated glomerular filtration rate in type 2 diabetes

Scientific Reports, 2018
Chronic inflammation plays a crucial role in the development/progression of diabetic kidney disease. The involvement of tumor necrosis factor (TNF)-related biomarkers [TNFα, progranulin (PGRN), TNF receptors (TNFR1 and TNFR2)] and uric acid (UA) in renal
Nozomu Kamei, M. Yamashita, Y. Nishizaki, Naotake Yanagisawa, S. Nojiri, Kanako Tanaka, Y. Yamashita, T. Shibata, Maki Murakoshi, Yusuke Suzuki, T. Gohda   +10 more
semanticscholar   +1 more source

Outcome of Patients With Lupus Nephritis Treated With an Anti‐CD40 Monoclonal Antibody According to Kidney Biopsy Features

Arthritis &Rheumatology, EarlyView.
Objective A phase 2 trial tested different doses of the anti‐CD40 monoclonal antibody BI 655064 as an add‐on therapy to the standard of care in patients with class III or IV lupus nephritis (LN) with active disease. A post hoc analysis showed a potential benefit of the higher tested doses (180 and 240 mg) versus a low dose (120 mg) or placebo.
Martina Uzzo, Helmut Schumacher, Juergen Steffgen, Simone Deutschel, David Jayne, Ingeborg Bajema   +5 more
wiley   +1 more source