Results 121 to 130 of about 279,299 (375)

Aberrant glycosylation of IgG in children with active lupus nephritis alters podocyte metabolism and causes podocyte injury

Arthritis &Rheumatology, Accepted Article.
Background Podocytes are integral to the maintenance of the glomerular filtration barrier. Their injury results in proteinuria and disease progression in lupus nephritis (LN). Aberrant IgG glycosylation drives podocyte injury in LN and leads to cytoskeletal rearrangement, motility changes and decreased nephrin production.
Rhea Bhargava, Rohit Upadhyay, Cong Zhao, Prasad Katakam, Scott Wenderfer, Jing Chen, Hua He, Richard Cummings, Maria G. Tsokos, George C. Tsokos   +9 more
wiley   +1 more source

Low glomerular filtration rate and risk of stroke: meta-analysis [PDF]

Objective To qualitatively and quantitatively investigate the link between a low estimated glomerular filtration rate (eGFR) at baseline and risk of future ...
Chang, Kuo-Hsuan, Chang, Shen-Chih, Lee, Meng, Liao, Hung-Wei, Ovbiagele, Bruce, Saver, Jeffrey L   +5 more
core   +2 more sources

Effect of long‐term voclosporin treatment on renal histology in patients with active lupus nephritis with repeat renal biopsies

Arthritis &Rheumatology, Accepted Article.
Objective This study characterized the impact of voclosporin on kidney histology in patients with lupus nephritis (LN) who had protocolized repeat kidney biopsies in the AURORA clinical trials. Methods Patients were randomized to voclosporin or placebo treatment for up to three years; all patients received mycophenolate mofetil and low‐dose ...
Brad H. Rovin, Clarissa Cassol, Samir V. Parikh, Amit Saxena, Neil Solomons, Vanessa Birardi, Ernie Yap, Clint W. Abner, David R.W. Jayne, Robert B. Huizinga   +9 more
wiley   +1 more source

Solanidine‐derived CYP2D6 phenotyping elucidates phenoconversion in multimedicated geriatric patients

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Phenoconversion, a genotype‐phenotype mismatch, challenges a successful implementation of personalized medicine. The aim of this study was to detect and determine phenoconversion using the solanidine metabolites 3,4‐seco‐solanidine‐3,4‐dioic acid (SSDA) and 4‐OH‐solanidine as diet‐derived cytochrome P450 2D6 (CYP2D6) biomarkers in a ...
Jens Andreas Sarömba, Julian Peter Müller, Jolanta Tupiec, Anjali Roeth, Berkan Kurt, Florian Kahles, Thea Laurentius, Cornelius Bollheimer, Julia C. Stingl, Katja S. Just   +9 more
wiley   +1 more source

Estimation of renal function in adult outpatients with normal serum creatinine

BMC Research Notes, 2019
Objective The aim of this study was to estimate the prevalence of renal insufficiency using estimated glomerular filtration rate (eGFR) among adult outpatients with normal SCr.
Temesgen Fiseha, Tizita Mengesha, Rahel Girma, Edosa Kebede, Angesom Gebreweld   +4 more
doaj   +1 more source

Patterns of Estimated Glomerular Filtration Rate Decline Leading to End-Stage Renal Disease in Type 1 Diabetes

Diabetes Care, 2016
OBJECTIVE The patterns of estimated glomerular filtration rate (eGFR) decline to end-stage renal disease (ESRD) in patients with type 1 diabetes has not been conclusively described.
J. Skupień, J. Warram, A. Smiles, R. Stanton, A. Krolewski   +4 more
semanticscholar   +1 more source

Advances in glomerular filtration rate estimation.

Sultan Qaboos University medical journal, 2014
NA
openaire   +3 more sources

Estimated glomerular filtration rate correlates poorly with four-hour creatinine clearance in critically ill patients with acute kidney injury. [PDF]

, 2013
Introduction. RIFLE and AKIN provide a standardised classification of acute kidney injury (AKI), but their categorical rather than continuous nature restricts their use to a research tool. A more accurate real-time description of renal function in AKI is
Kirwan, CJ, Macphee, IA, Philips, BJ
core   +2 more sources

The effect of severe renal impairment on the pharmacokinetics, safety and tolerability of balcinrenone

British Journal of Clinical Pharmacology, EarlyView.
Aims The aim of this phase 1 trial was to assess the pharmacokinetics, safety and tolerability of balcinrenone (previously AZD9977) in participants with severe renal impairment vs. those with normal renal function. Methods Participants with severe renal impairment (estimated glomerular filtration rate [eGFR] < 30 mL/min/1.73 m2) not on dialysis were ...
Chandrali S. Bhattacharya, Hans Ericsson, Susanne Johansson, Joanna Parkinson, Simina M. Boca, Ye Yang, Maria Heijer, Greggory Housler, Maria Leonsson‐Zachrisson, Judith Hartleib‐Geschwindner, Patricia Ely Pizzato   +10 more
wiley   +1 more source

The impact of stone composition on renal function

Urology Annals, 2018
Background: Nephrolithiasis is a common condition that has various classifications according to stone composition. Stone formation can affect renal function; it can be a strong risk factor for chronic kidney disease (CKD).
Anmar Nassir, Hesham Saada, Taghreed Alnajjar, Jomanah Nasser, Waed Jameel, Soha Elmorsy, Hattan Badr   +6 more
doaj   +1 more source