Results 131 to 140 of about 5,778,717 (303)

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

Blood pressure and estimated glomerular filtration rate – heritability analysis.

, 2013
h2 – narrow sense heritability, SE – standard error, P-value – level of statistical significance, GRAPHIC – Genetic Regulation of Arterial Pressure of Humans in the Community, SCS – Silesian Cardiovascular Study, eGFR – estimated glomerular filtration ...
Gerard Waeber (2826815), Radoslaw Debiec (232393), David Lambert (504743), Kijoung Song (28912), Lukasz Wojnar (504741), Pawel Bogdanski (504740), Ewa Zukowska-Szczechowska (439941), Nilesh J. Samani (60118), John R. Thompson (256150), Peter Vollenweider (93049), Lisa D. Bloomer (504739), Fadi J. Charchar (419589), Matthew Denniff (439939), Katarzyna Musialik (504742), Paraskevi Christofidou (504738), Dawn Waterworth (160856), Maciej Tomaszewski (232381)   +16 more
core   +1 more source

Bland-Altman plot of estimated glomerular filtration rate using serum creatinine and cystatin-C.

, 2020
Bland-Altman plot of estimated glomerular filtration rate using serum creatinine and cystatin-C.
Joshua Z. Willey (5963651), Ken Cheung (1691500), S. Ali Husain (5963648), Ralph L. Sacco (7715633), Clinton B. Wright (7851749), Mitchell S. V. Elkind (7851746), Myles Wolf (5728646), Sumit Mohan (498540), Yeseon Park Moon (5851280)   +8 more
core   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

Population pharmacokinetics of levofloxacin in breastmilk in patients with rifampicin‐resistant tuberculosis

British Journal of Clinical Pharmacology, EarlyView.
Levofloxacin is a widely used antibiotic included in rifampicin‐resistant tuberculosis (RR‐TB) treatment. Data describing levofloxacin concentrations in breastmilk and infant exposure are limited. We analysed data from two South African studies of breastfeeding women receiving levofloxacin (750–1000 mg daily) for RR‐TB.
Sharon Sawe, Lufina Tsirizani, Buyisile Mkhize, Lubbe Wiesner, Gary Maartens, Francesca Conradie, Richard Court, Marian Loveday, Catriona Waitt, Paolo Denti   +9 more
wiley   +1 more source

Influence of albuminuria and glomerular filtration rate on blood pressure response to antihypertensive drug therapy

, 2008
John M Flack1, Karl Duncan2, Suzanne E Ohmit3, Ruth Quah1, Xuefeng Liu1, Preeti Ramappa1, Sandra Norris1, Lowell Hedquist1, Amanda Dudley1, Samar A Nasser11Division of Translational Research and Clinical Epidemiology, Department of Internal Medicine ...
Karl Duncan, Xuefeng Liu, John M Flack, et al, Suzanne E Ohmit, Ruth Quah   +5 more
core  

Calibrating estimated glomerular filtration rate cut points in adults with diabetes

, 2022
Calibrating estimated glomerular filtration rate cut points in adults with ...
EI Ekinci (14448807), N Zafari (13479952), L Churilov (5578286), N Torkamani (13479955), RJ Macisaac (14471718), Mojtaba Lotfaliany Abrand Abadi (13085616)   +5 more
core  

Metabolomic investigation of cisplatin‐induced acute kidney injury in paediatric cancer patients

British Journal of Clinical Pharmacology, EarlyView.
Aim Cisplatin causes acute kidney injury (AKI) in approximately 46% of paediatric cancer patients who receive it. Serum creatinine (SCr) is a poor biomarker of cisplatin nephrotoxicity, because there is a delay between cisplatin infusion and SCr elevation.
Yong Jin Lim, Amy Thachil, Kelly McMahon, Ross T. Tsuyuki, S. Rod Rassekh, Lesley G. Mitchell, Prasad Devarajan, Cherry Mammen, Bruce C. Carleton, Geoffrey D. E. Cuvelier, Victor A. Lewis, Colin J. D. Ross, Alexandra P. Zorzi, Sylvain Baruchel, Raveena Ramphal, Eric Bouffet, Mathieu Lemaire, Tom D. Blydt‐Hansen, Brad L. Urquhart, The Applying Biomarkers to Minimize Long‐Term Effects of Childhood/Adolescent Cancer Treatment (ABLE) Research Study Group, Tom Blydt‐Hansen, Bruce C. Carleton, Geoff D. E. Cuvelier, Sunil Desai, Prasad Devarajan, Conrad Fernandez, Adam Fleming, Paul Gibson, Caroline Laverdiere, Victor Lewis, Mary L. McBride, Bruno Michon, Shahrad Rod Rassekh, Colin J. D. Ross, Christine Sabapathy, Kirk R. Schultz, Michael Zappitelli, Alexandra Zorzi   +37 more
wiley   +1 more source

Pharmacokinetic profiling of imatinib in relation to CYP3A4 activity in leukaemia patients

British Journal of Clinical Pharmacology, EarlyView.
Aim Imatinib pharmacokinetics exhibit large interindividual variability because of differences in CYP3A4 activity—the main imatinib‐metabolizing enzyme. While therapeutic drug monitoring is effective, it requires steady‐state conditions and frequent sampling.
Anna Sofie Buhl Rasmussen, Mathilde Rønne Koch, Cecilie Utke Rank, Christen Lykkegaard Andersen, Allan Weimann, Maria Thastrup, Tianwu Yang, Trine Meldgaard Lund, Ib Jarle Christensen, Flemming Nielsen, Tore Bjerregaard Stage, Sara Bisgaard Jensen, Mette Klarskov Andersen, Kjeld Schmiegelow, Kim Dalhoff   +14 more
wiley   +1 more source

Correlation between PCSK9 and estimated glomerular filtration rate (GFR) assessed by Spearman test.

, 2016
Correlation between PCSK9 and estimated glomerular filtration rate (GFR) assessed by Spearman test.
Christian Werner (351232), Michael Böhm (65063), Simone Lennartz (847588), Danilo Fliser (360750), Kyrill S. Rogacev (360745), Marcus E. Kleber (106276), Adam M. Zawada (847589), Günther Silbernagel (106282), Sarah Seiler (847586), Ulrich Laufs (360751), Insa Emrich (847587), Hubert Scharnagl (435522), Gunnar H. Heine (360752), Winfried März (106288)   +13 more
core   +1 more source