Results 151 to 160 of about 6,936,552 (305)

Cefepime exposure in prolonged or intermittent infusion in critically ill children

British Journal of Clinical Pharmacology, EarlyView.
Aims Cefepime is commonly used in critically ill children for whom there is a high between‐subject variability. To reach the therapeutic pharmacokinetic (PK) target in critically ill patients, prolonged infusion of beta‐lactams seems to be the most efficient.
Marc Hobeika, Deborah Hirt, Emmanuelle Bille, Sihem Benaboud, Julie Toubiana, Pierre‐Louis Léger, Jérôme Rambaud, Agathe Béranger, Delphine Callot, Sylvain Renolleau, Jean‐Marc Treluyer, Mehdi Oualha, Noémie de Cacqueray   +12 more
wiley   +1 more source

Translational development of crisugabalin for neuropathic pain

British Journal of Clinical Pharmacology, EarlyView.
Abstract Crisugabalin (HSK16149) is a next‐generation α2δ ligand developed to preserve the mechanistic rationale of gabapentinoids while refining target engagement and exposure‐related tolerability constraints. We performed a translational review of molecular/structural studies, in vivo pharmacology and behavioural safety assessments, phase I clinical ...
Rafael Batista João, Jilly Octoria Tagore Chan, Luísa Mendes Araújo, André Batista João, Raquel Mattos Filgueiras, Paulo César Ragazzo   +5 more
wiley   +1 more source

Urological impact of race-free estimated glomerular filtration rate equations [PDF]

International Brazilian Journal of Urology
Natália Dalsenter Avilez, José Ignacio Nolazco, Steven Lee Chang, Leonardo O. Reis   +3 more
doaj   +1 more source

CYP3A5 genetic variability influences sildenafil and metabolite in pulmonary hypertension

British Journal of Clinical Pharmacology, EarlyView.
Aim Interindividual variability in sildenafil response among pulmonary hypertension patients (PH) may be influenced by CYP3A5 polymorphisms. CYP3A5*3 allele reduces CYP3A5 activity and affects sildenafil metabolism. This study investigated the associations between CYP3A5 genotype and plasma concentrations of sildenafil and N‐desmethyl sildenafil, as ...
Pranisa Wongwien, Burabha Pussadhamma, Sirimas Kanjanawart, Thikhumporn Areesinpitak, Nontaya Nakkam, Chingching Foocharoen, Wichittra Tassaneeyakul, Suda Vannaprasaht   +7 more
wiley   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality

BMEMat, EarlyView.
Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim, Marwa Ahmed El‐Naka, Wedad M. Nageeb, Atta Ullah Khan, Noura M. Seleem, Aliaa Abdelghafar, Doaa Zamel, Yang Liu, Qigai He, Wentao Li   +9 more
wiley   +1 more source

KORELASI ANTARA KADAR HEMOGLOBIN A1C DENGAN ESTIMATED GLOMERULAR FILTRATION RATE PADA DEWASA

Glycated hemoglobin has been considered an indicator of long-term glycemic control that may be associated with renal function; however, previous studies investigating its relationship with estimated glomerular filtration rate in adult populations have ...
Tama, Bisma Narendra, Natadidjaja, Ronald Irwanto   +1 more
core   +1 more source

Calcified Plaque Detachment: Alternative Calcified Plaque Modification After Coronary Intravascular Lithotripsy

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Calcified plaque (CP) detachment (CD) and calcium fracture (CF) can occur following coronary intravascular lithotripsy (IVL). The extent to which CF alone facilitates stent expansion during CP modification with IVL remains unclear. Aims This study aimed to investigate the clinical implications of IVL‐induced CD.
Daisuke Naito, Akiko Matsuo, Takeru Kasahara, Keisuke Ota, Shinsaku Matsunaga, Norio Nakajima   +5 more
wiley   +1 more source

VERMONT μQFR: Diagnostic Accuracy of Murray Law‐Based 2D‐μQFR Compared to 3D‐μQFR and vFFR

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Murray law‐based quantitative flow ratio (μQFR) is an angiography‐derived physiological index that utilizes a single angiographic projection with artificial intelligence‐guided vessel segmentation. Aims To evaluate the diagnostic accuracy and time efficacy of 2D‐μQFR against wire‐based fractional flow reserve (FFR ≤ 0.80), compare ...
Daniel Akrawi, Krishna Kadappu, James Xu, Tamer Yousef Naguib Badie, Oliver Gibbs, Hashim Kachwalla, Phong T. D. Nguyen, Rahul Kurup, Upul Premawardhana, Justyn Huang, Hao Tran, Kavie Soosapilla, Jim Basilakis, Aiden O'loughlin, Annemarie Hennessy, Giuseppe Femia, Sidney Lo   +16 more
wiley   +1 more source

Evaluation of Treatment Response of Calcified Nodules and Nodular Calcified Lesions Using Mean Density on Coronary Computed Tomography Angiography

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Calcified nodules (CN) and nodular calcifications (NC) present significant challenges during percutaneous coronary intervention (PCI) because of their protruding morphology and high rigidity, which often result in inadequate stent expansion and suboptimal procedural outcomes.
Akito Setoguchi, Keita Iyama, Ryosuke Iwasaki, Saburo Kusumoto, Yoshiyuki Doi, Tatsuya Nunohiro, Masayoshi Takeno, Koji Maemura   +7 more
wiley   +1 more source