Results 161 to 170 of about 5,778,717 (303)

Clinical Outcomes of Drug‐Eluting Stents and Drug‐Coated Balloons in Tortuous Small Coronary Lesions

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background In small, tortuous coronary lesions, the long‐term comparative performance of drug‐coated balloon (DCB) angioplasty versus drug‐eluting stent (DES) treatment remains uncertain, despite both strategies being widely used in contemporary percutaneous coronary intervention (PCI) practice. Aims This study aimed to compare 3‐year clinical
Shunichiro Ishio, Takashi Nagasaka, Ryota Taniuchi, Shiro Amanai, Yohei Ishibashi, Noriaki Takama, Hideki Ishii   +6 more
wiley   +1 more source

Evaluating the Impact of Enhanced Stent Visualization on PCI Outcomes in Older Patients With Multivessel Disease

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Optimal stent expansion is a key determinant of long‐term outcomes after PCI. Intravascular imaging provides the most accurate assessment of stent deployment but remains underused, especially in older patients with MI and multivessel disease.
Marta Cocco, Alberto Sarti, Filippo Maria Verardi, Serena Caglioni, Jacopo Farina, Carlo Penzo, Carlo Tumscitz, Matteo Serenelli, Renè Tezze, Anna Cantone, Andrea Erriquez, Gianluca Campo, Simone Biscaglia   +12 more
wiley   +1 more source

Estimated Glomerular Filtration Rate, Nutritional Factors, and Their Relationships With Homocysteine in Community-Dwelling Older Adults. [PDF]

J Nutr Metab
Li HL, Chuang YM, Huang PJ, Chang PS.
europepmc   +1 more source

Americentrism in estimation of glomerular filtration rate equations

Kidney International, 2022
Pierre Delanaye, Hans Pottel, Richard J. Glassock   +2 more
openaire   +4 more sources

Virtual Twin Approach Using Physiologically Based Pharmacokinetic Modeling to Support Precision Dosing of Valproic Acid in Geriatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Personalized dosing is particularly important for drugs with narrow therapeutic indices in geriatric patients, who exhibit substantial physiological variability and limited pharmacokinetic (PK) evidence to guide individualized dose selection. Valproic acid (VPA) is an effective treatment option for bipolar disorder in older adults, yet dosing largely ...
Yoo Jin Jang, Dong‐Gyu Heo, Eunjin Hong   +2 more
wiley   +1 more source

Incident Hypertension in Young Adults With a Mild Estimated Glomerular Filtration Rate Reduction. [PDF]

J Am Heart Assoc
Ahmed S, Hussain J, Grubic N, Akbari A, Ravani P, Tanuseputro P, Hundemer GL, Ramsay T, Tangri N, Bugeja A, Knoll GA, Maneul D, Sud M, Dhaliwal S, Chanchlani R, Sood MM.   +15 more
europepmc   +1 more source

Effects of Trimethoprim on Three Previously Proposed Putative Biomarkers for OCT2/MATE‐Mediated Renal Drug‐Drug Interactions in Healthy Volunteers

Clinical Pharmacology &Therapeutics, EarlyView.
Regulatory agencies request the assessment of the potential of new drugs to cause transporter‐mediated drug‐drug interactions (DDI). This assessment can be improved by integrating endogenous biomarkers during drug development. Regarding the renal excretion of drugs such as metformin, the organic cation transporter (OCT) 2 and multidrug and toxin ...
Jana Picurová, Fabian Müller, Daniel Auge, Jörg König, Martin F. Fromm, Arne Gessner   +5 more
wiley   +1 more source

Impact of Estimated Glomerular Filtration Rate Equations on Vancomycin Dosing and Treatment Outcomes. [PDF]

Drug Des Devel Ther
Gu Q, Chen Y, Zhao A, Zhu H, Wang J, Kong M, Chen X, Liu Y, Zhang H, Chen D.   +9 more
europepmc   +1 more source

Operationalizing Precision Medicine in Drug Development: Predictive Biomarkers, Companion Diagnostics, and Regulatory Pathways

Clinical Pharmacology &Therapeutics, EarlyView.
Precision medicine offers the opportunity to improve the benefit–risk profile of new therapies by prospectively identifying patients most likely to respond or least likely to experience harm; however, its systematic integration into drug development remains inconsistent outside oncology.
Ingrid Holst‐Laubjerg, José M.A. Moreira   +1 more
wiley   +1 more source

Correction: Prediction of estimated glomerular filtration rate slope and kidney prognosis of patients with chronic kidney disease. [PDF]

Sci Rep
Nagasu H, Nakashima T, Ihara K, Fujimori R, Goto T, Nitta D, Kishi S, Sasaki T, Kashihara N.   +8 more
europepmc   +1 more source