Results 31 to 40 of about 84,258 (216)

On a fundamental result in van der Corput's method of estimating exponential sums [PDF]

open access: yesActa Arithmetica, 1999
Let \(f\) be a real function with continuous derivatives up to the third order in \([a,b]\). \(f''(x)\) does not change its sign in the interval. Then van der Corput's transformation of the exponential sum \[ S= \sum_{a\leq m\leq b} e^{2\pi if(m)} \] reads as follows: \[ S= e^{\pi i/4} \sum_{f'(a)\leq \nu\leq f'(b)} \frac{1}{\sqrt{|f''(x_\nu)|}} e^{2 ...
openaire   +1 more source

Moments and oscillations of exponential sums related to cusp forms

open access: yes, 2016
We consider large values of long linear exponential sums involving Fourier coefficients of holomorphic cusp forms. The sums we consider involve rational linear twists $e(nh/k)$ with sufficiently small denominators.
Vesalainen, Esa V.
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

Mean values of Dirichlet polynomials and applications to linear equations with prime variables

open access: yes, 2004
We prove a new mean-value theorem for Dirichlet polynomials with coefficients given by the von Mangoldt function. We then use our theorem to derive new estimates for certain exponential sums over primes.
Angel V. Kumchev   +2 more
core   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

On cubic polynomials I. Hua's estimate of exponential sums

open access: yesMonatshefte für Mathematik, 1982
Hua andChen gave estimates of sums\(\sum\limits_{x = 1}^q {e(\mathfrak{F}(x))} \) wheree(z)=e2πiz and\(\mathfrak{F}\) is a polynomial of the typef(x)/q wheref(x)=akxk+...+a1x with integer coefficients having gcd (q, ak,...,a1)=1 But no good estimates hold for these sums whenq is small in comparison tok.
openaire   +2 more sources

Decomposition of exponential sums based on subspace and its application in channel estimation

open access: yesDianxin kexue, 2023
The problem of the decomposition of an exponential sum sequence is a classical mathematical problem.Prony method and Prony-Kung method are the classical methods to solve this problem.The Prony-Kung method was analyzed in detail from the point of view of support subspace.On this basis, it was proved theoretically that the problem of the decomposition of
Zhiwei WU   +4 more
openaire   +2 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

Home - About - Disclaimer - Privacy