Results 51 to 60 of about 87,373 (257)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Families of generalized Kloosterman sums [PDF]
, 2013 We construct p-adic relative cohomology for a family of toric exponential sums which generalize the classical Kloosterman sums. Under natural hypotheses such as quasi-homogeneity and nondegeneracy, this cohomology is acyclic except in the top dimension ...
Haessig, C. Douglas, Sperber, Steven
core
Fourier dimension and spectral gaps for hyperbolic surfaces
, 2017 We obtain an essential spectral gap for a convex co-compact hyperbolic surface $M=\Gamma\backslash\mathbb H^2$ which depends only on the dimension $\delta$ of the limit set.
Bourgain, Jean, Dyatlov, Semyon
core +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Computing Dirichlet character sums to a power-full modulus
, 2014 The Postnikov character formula is used to express large portions of a Dirichlet character sum in terms of quadratic exponential sums. The quadratic sums are then computed using an analytic algorithm previously derived by the author.
Hiary, Ghaith A.
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Almost all palindromes are composite
, 2004 We study the distribution of palindromic numbers (with respect to a fixed base $g\ge 2$) over certain congruence classes, and we derive a nontrivial upper bound for the number of prime palindromes $n\le x$ as $x\to\infty$.
Banks, William D. +2 more
core +2 more sources
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Exponential sums with automatic sequences
, 2017 We show that automatic sequences are asymptotically orthogonal to periodic exponentials of type $e_q(f(n))$, where $f$ is a rational fraction, in the P\'olya-Vinogradov range.
Drappeau, Sary, Müllner, Clemens
core +3 more sources