Results 31 to 40 of about 84,599 (243)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Families of generalized Kloosterman sums [PDF]
, 2013 We construct p-adic relative cohomology for a family of toric exponential sums which generalize the classical Kloosterman sums. Under natural hypotheses such as quasi-homogeneity and nondegeneracy, this cohomology is acyclic except in the top dimension ...
Haessig, C. Douglas, Sperber, Steven
core
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Fourier dimension and spectral gaps for hyperbolic surfaces
, 2017 We obtain an essential spectral gap for a convex co-compact hyperbolic surface $M=\Gamma\backslash\mathbb H^2$ which depends only on the dimension $\delta$ of the limit set.
Bourgain, Jean, Dyatlov, Semyon
core +1 more source
Estimations on some hybrid exponential sums related to Kloosterman sums
TURKISH JOURNAL OF MATHEMATICS, 2021 Summary: In this paper, we revisit the bounds of the mixed exponential sums introduced by \textit{X. X. Lv} and \textit{W. P. Zhang} [Acta Math. Sin., Engl. Ser. 36, No. 2, 196--206 (2020; Zbl 1472.11220)]. Moreover, we give some estimations for some new hybrid exponential sums related to Kloosterman sums over finite fields of odd characteristic by ...
Yingjie CHENG +3 more
openaire +2 more sources
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Some extremal functions in Fourier analysis, II
, 2008 We obtain extremal majorants and minorants of exponential type for a class of even functions on $\R$ which includes $\log |x|$ and $|x|^\alpha$, where $-1 < \alpha < 1$. We also give periodic versions of these results in which the majorants and minorants
Carneiro, Emanuel, Vaaler, Jeffrey D.
core +2 more sources
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Addendum: Level Spacings for Integrable Quantum Maps in Genus Zero
, 2000 In this addendum we strengthen the results of math-ph/0002010 in the case of polynomial phases. We prove that Cesaro means of the pair correlation functions of certain integrable quantum maps on the 2-sphere at level N tend almost always to the Poisson ...
Zelditch, Steve
core +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source