Results 61 to 70 of about 841,625 (297)

Harnack estimate for the Endangered Species Equation [PDF]

Proceedings of the American Mathematical Society, 2015
We prove a differential Harnack inequality for the Endangered Species Equation, a nonlinear parabolic equation. Our derivation relies on an idea related to the parabolic maximum principle. As an application of this inequality, we will show that positive solutions to this equation must blowup in finite time.
Cao, Xiaodong, Cerenzia, Mark, Kazaras, Demetre   +2 more
openaire   +3 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Prevalence of diabetes and prediabetes among working-age adults and influencing factors of new-onset diabetes: a five-year cohort study (2018–2023)

Frontiers in Endocrinology
BackgroundDiabetes and prediabetes in the young and middle-aged population represent a significant public health challenge in China. In recent years, the prevalence of diabetes has gradually increased within this group.
Jing Tan, Mingzhu Chen, Yang Lei, Xiaofen Shi, Cuiping Cao, Naili Du, Yuyou Yao, Xiaojuan Yao   +7 more
doaj   +1 more source

Plug-in semiparametric estimating equations [PDF]

, 1995
In parametric regression problems, estimation of the parameter of interest is typically achieved via the solution of a set of unbiased estimating equations. We are interested in problems where in addition to this parameter, the estimating equations consist of an unknown nuisance function which does not depend on the parameter.
Gutierrez, Roberto G., Carroll, Raymond J.   +1 more
openaire   +2 more sources

GFR Estimating Equations [PDF]

Clinical Journal of the American Society of Nephrology, 2013
Summary The application of serum creatinine and cystatin C in patients with CKD has been limited to using estimated glomerular filtration rate (eGFR). Criteria for choosing the best GFR estimating equation are 1) accuracy in estimating measured GFR, 2) optimal discrimination of clinical outcomes, and 3) association with CKD ...
Andrew D, Rule, Richard J, Glassock
openaire   +2 more sources

A priori estimates for free boundary problem of incompressible inviscid magnetohydrodynamic flows [PDF]

, 2013
In the present paper, we prove the a priori estimates of Sobolev norms for a free boundary problem of the incompressible inviscid MHD equations in all physical spatial dimensions $n=2$ and 3 by adopting a geometrical point of view used in Christodoulou ...
Hao, Chengchun, Luo, Tao
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Scaling bounds on dissipation in turbulent flows

, 2015
We present a new rigorous method for estimating statistical quantities in fluid dynamics such as the (average) energy dissipation rate directly from the equations of motion.
Seis, Christian
core   +1 more source

Body composition in Nepalese children using isotope dilution: the production of ethnic-specific calibration equations and an exploration of methodological issues. [PDF]

, 2015
Background. Body composition is important as a marker of both current and future health. Bioelectrical impedance (BIA) is a simple and accurate method for estimating body composition, but requires population-specific calibration equations. Objectives. (1)
Chaube, SS, Costello, A, Devakumar, D, Grijalva-Eternod, CS, Manandhar, DS, Osrin, D, Roberts, S, Saville, NM, Wells, JC   +8 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source