Results 41 to 50 of about 621,525 (301)

Extraction of the underlying structure of systematic risk from non-Gaussian multivariate financial time series using independent component analysis: Evidence from the Mexican stock exchange [PDF]

open access: yes, 2018
Regarding the problems related to multivariate non-Gaussianity of financial time series, i.e., unreliable results in extraction of underlying risk factors -via Principal Component Analysis or Factor Analysis-, we use Independent Component Analysis (ICA ...
Ladrón de Guevara Cortés, Rogelio   +2 more
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

The t-Distribution Approach to the Second-Order Multiresponse Surface Model of Paracetamol Tablets Quality Characteristics

open access: yesApplied Sciences, 2023
The normal distribution approach is often used in regression analysis at the Response Surface Methodology (RSM) modeling stage. Several studies have shown that the normal distribution approach has drawbacks compared to the more robust t-distribution ...
Pismia Sylvi   +3 more
doaj   +1 more source

Multivariate Discriminant Analysis and Maximum Penalized Likelihood Density Estimation

open access: yesJournal of the Royal Statistical Society Series B: Statistical Methodology, 1995
SUMMARY A new theoretical point of view is discussed in the framework of density estimation. The multivariate true density, viewed as a prior or penalizing factor in a Bayesian framework, is modelled by a Gibbs potential. Estimating the density consists in maximizing the posterior.
Rasson, Jean-Paul, Granville, Vincent
openaire   +3 more sources

Customized design of hearing aids using statistical shape learning [PDF]

open access: yes, 2008
3D shape modeling is a crucial component of rapid prototyping systems that customize shapes of implants and prosthetic devices to a patient’s anatomy.
K. Zhou   +6 more
core   +2 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

Multivariate Tail Coefficients: Properties and Estimation

open access: yesEntropy, 2020
Multivariate tail coefficients are an important tool when investigating dependencies between extreme events for different components of a random vector.
Irène Gijbels   +2 more
doaj   +1 more source

Estimating within‐study covariances in multivariate meta‐analysis with multiple outcomes [PDF]

open access: yesStatistics in Medicine, 2012
Multivariate meta‐analysis allows the joint synthesis of effect estimates based on multiple outcomes from multiple studies, accounting for the potential correlations among them. However, standard methods for multivariate meta‐analysis for multiple outcomes are restricted to problems where the within‐study correlation is known or where individual ...
Wei, Yinghui, Higgins, Julian Pt
openaire   +4 more sources

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

open access: yesFEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti   +3 more
wiley   +1 more source

Exploring Mean Annual Precipitation Values (2003–2012) in a Specific Area (36°N–43°N, 113°E–120°E) Using Meteorological, Elevational, and the Nearest Distance to Coastline Variables

open access: yesAdvances in Meteorology, 2016
Gathering very accurate spatially explicit data related to the distribution of mean annual precipitation is required when laying the groundwork for the prevention and mitigation of water-related disasters.
Fushen Zhang   +3 more
doaj   +1 more source

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