Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Counterfactual prediction from machine learning models: transportability and joint analysis for model development and evaluation using multi-source data. [PDF]
Diagn Progn ResVoter SC +5 more
europepmc +1 more source
Particle filter state estimator for large urban networks
, 2011 Nicolae Marinică, René Boel
openalex +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
A statistical inference framework for FSNBLR: Modeling underdeveloped regional status in Eastern Indonesia. [PDF]
MethodsXZulfadhli M +4 more
europepmc +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Estimation of the transition rates in the illness-death model for chronic diseases from aggregated current status data: a feasibility and simulation study. [PDF]
Front EpidemiolBrinks R, Mohammadi Saem M, Voß S.
europepmc +1 more source
An Exact Multiple-Time-Step Variational Formulation for the Committor and the Transition Rate. [PDF]
J Phys Chem BLorpaiboon C, Weare J, Dinner AR.
europepmc +1 more source
Multiple Comparisons With Overdispersed Multinomial Data: Methods, Properties and Application. [PDF]
Pharm StatBudig S, Vogel C, Schaarschmidt F.
europepmc +1 more source