Results 261 to 270 of about 1,012,468 (372)

Bayesian estimation of HIV acquisition dates for prevention trials. [PDF]

mBio
Rossenkhan R, Giorgi EE, Shao D, Ludwig J, Labuschagne P, Magaret CA, Ndung'u T, Muema D, Gounder K, Dong KL, Walker BD, Rolland M, Robb ML, Eller LA, Sawe F, Nitayaphan S, Grebe E, Busch MP, Delaney KP, Facente S, Carpp LN, deCamp AC, Huang Y, Korber B, Juraska M, Rudnicki E, Kosmider E, Reeves DB, Mayer BT, Hural J, Deng W, Westfall DH, Yssel A, Matten D, Bhattacharya T, Corey L, Gilbert PB, Williamson C, Mullins JI, Edlefsen PT.   +39 more
europepmc   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Intrasire and Intracow Regressions of Lactation Records on Herdmate Performance: Use, Estimators, and Biases

, 1974
I.L. Mao
openalex   +1 more source

Development of the generalized ridge estimator for the Poisson-Inverse Gaussian regression model with multicollinearity. [PDF]

Sci Rep
Almulhim FA, Hammad AT, Bakr ME, Balogun OS, Habineza A, Abd El-Raouf MM.   +5 more
europepmc   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Statistical Inference for High-Dimensional Heteroscedastic Partially Single-Index Models. [PDF]

Entropy (Basel)
Fang J, Tian Z.
europepmc   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

A multidimensional Newton-Raphson method and its applications to the existence of asymptotic Fn-estimators and their stochastic expansions

, 1977
R. Michel
openalex   +1 more source

Doubly Robust Estimation of Marginal Cumulative Incidence Curves for Competing Risk Analysis. [PDF]

Stat Med
van Hage P, le Cessie S, van Maaren MC, Putter H, van Geloven N.   +4 more
europepmc   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source