Results 71 to 80 of about 253,519 (319)

On Improved Loss Estimation for Shrinkage Estimators

open access: yesStatistical Science, 2012
Let $X$ be a random vector with distribution $P_θ$ where $θ$ is an unknown parameter. When estimating $θ$ by some estimator $φ(X)$ under a loss function $L(θ,φ)$, classical decision theory advocates that such a decision rule should be used if it has suitable properties with respect to the frequentist risk $R(θ,φ)$. However, after having observed $X=x$,
Fourdrinier, Dominique, Wells, Martin T.
openaire   +3 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

The multivariate least trimmed squares estimator. [PDF]

open access: yes
In this paper we introduce the least trimmed squares estimator for multivariate regression. We give three equivalent formulations of the estimator and obtain its breakdown point. A fast algorithm for its computation is proposed.
Croux, Christophe   +2 more
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

A Bistochastic Nonparametric Estimator [PDF]

open access: yes
We explore the relevance of adopting a bistochastic nonparametric estimator. This estimator has two main implications. First, the estimator reduces variability according to the robust criterion of second-order stochastic (and Lorenz) dominance. This is a
Rafael Salas, Juan Gabriel Rodríguez
core  

A TIME-OPTIMAL ALGORITHM FOR THE ESTIMATION OF CONTACT DISTRIBUTION FUNCTIONS OF RANDOM SETS

open access: yesImage Analysis and Stereology, 2011
This paper presents a linear-time and therefore time-optimal algorithm for the estimation of distance distribution functions and contact distribution functions of random sets.
Johannes Mayer
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Bootstrapping heteroskedasticity consistent covariance matrix estimator [PDF]

open access: yes
Recent results of Cribari-Neto and Zarkos (1999) show that bootstrap methods can be successfully used to estimate a heteroskedasticity robust covariance matrix estimator. In this paper, we show that the wild bootstrap estimator can be calculated directly,
Emmanuel Flachaire
core  

Application of the Scaling Functions to Nonparametric Regression [PDF]

open access: yesInformatică economică, 2007
For estimating regression function we can use many proceedings. In this paper, we have chosen to apply scaling functions to the estimation of regression functions.
doaj  

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