Results 81 to 90 of about 253,519 (319)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
A U-statistic estimator for the variance of resampling-based error estimators [PDF]
, 2013 We revisit resampling procedures for error estimation in binary classification in terms of U-statistics. In particular, we exploit the fact that the error rate estimator involving all learning-testing splits is a U-statistic.
De Bin, Riccardo +7 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Application Regression Method in the Calculation Of Indicators Economic Risk [PDF]
Revista Română de Statistică, 2013 The objective of this Article is to show that economic risk is influenced by multiple factors, and by regression method can establish the extent of influence of each factor.
Florina Roman Stan
doaj
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
A Pairwise Difference Estimator for Partially Linear Spatial Autoregressive Models [PDF]
Su and Jin (2010) develop for partially linear spatial autoregressive (PL-SAR) model a profile quasimaximum likelihood based estimation procedure. More recently, Su (2011) proposes for this model a semiparametric GMM estimator.
Zhengyu Zhang
core
The raise estimator estimation, inference, and properties
Communications in Statistics - Theory and Methods, 2017 Several methods using different approaches have been developed to remedy the consequences of collinearity. To the best of our knowledge, only the raise estimator proposed by García et al. (Citation2010) deals with this problem from a geometric perspective.
Salmerón Gómez, Román +3 more
openaire +2 more sources
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Multicollinearity and maximum entropy leuven estimator [PDF]
Multicollinearity is a serious problem in applied regression analysis. Q. Paris (2001) introduced the MEL estimator to resolve the multicollinearity problem.
Sougata Poddar
core
Consistency and Asymptotic Normality of Estimator for Parameters in Multiresponse Multipredictor Semiparametric Regression Model [PDF]
, 2022 A multiresponse multipredictor semiparametric regression (MMSR) model is a combi-nation of parametric and nonparametric regressions models with more than one predictor and response variables where there is correlation between responses.
Nur Chamidah, S.Si., M.Si +2 more
core