Results 121 to 130 of about 12,682 (158)

Synthesis of Novel Europium-Labeled Estradiol Derivatives for Time-Resolved Fluoroimmunoassays

Bioconjugate Chemistry, 1999
The O-(5-carboxypentyl)-, O-(4-aminobutyl)-, O-(6-aminohexyl)oximes of 2- and 4-formylestradiol as well as the 4-carboxyethylthioether derivative of estradiol were synthesized. These estradiol derivatives were characterized using IR-, 1H-, and 13C NMR spectroscopy. All synthesized estradiol derivatives were labeled with europium chelates.
N, Meltola, P, Jauria, P, Saviranta, H, Mikola   +3 more
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Synthesis and characterization of estradiol derivatives

2008
Synthesis and characterization of estradiol derivatives were discussed.
Zorc, Branka, Zovko Končić, Marijana, Novak, Predrag   +2 more
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17β-Estradiol Mobilizes Bone Marrow–Derived Endothelial Progenitor Cells to Tumors

Cancer Research, 2008
Abstract Neovascularization is critical for tumor growth and development. The cellular mediators for this process are yet to be defined. We discovered that bone marrow–derived endothelial progenitor cells (BM-EPC), having the phenotype (CD133+, CD34+, VEGFR-2+), initiate neovascularization in response to TG1-1 mammary cells implanted ...
Robert, Suriano, Devyani, Chaudhuri, Raja Singh, Johnson, Erin, Lambers, Badithe T, Ashok, Raj, Kishore, Raj K, Tiwari   +6 more
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Inhibition of steroid sulfatase with 4-substituted estrone and estradiol derivatives

Bioorganic & Medicinal Chemistry, 2011
Steroid sulfatase (STS) catalyzes the desulfation of biologically inactive sulfated steroids to yield biologically active desulfated steroids and is currently being examined as a target for therapeutic intervention for the treatment of breast cancer. We previously demonstrated that 4-formyl estrone is a time- and concentration-dependent inhibitor of ...
Chau-Minh, Phan, Yong, Liu, Byoung-moo, Kim, Yaser, Mostafa, Scott D, Taylor   +4 more
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Pathway of 17β-estradiol degradation by Nitrosomonas europaea and reduction in 17β-estradiol-derived estrogenic activity

Environmental Chemistry Letters, 2010
In recent years, natural and synthetic estrogens have been recognized as endocrine disruptors in aquatic organisms. Although natural and synthetic estrogens are known to be degraded by microbes, only limited information about their degradation pathways is available.
Satoshi Nakai, Anri Yamamura, Shou Tanaka, Jianghong Shi, Megumi Nishikawa, Yutaka Nakashimada, Masaaki Hosomi   +6 more
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Synthesis of 7alpha-substituted derivatives of 17beta-estradiol.

Steroids, 2006
Estrogen receptor (ER) pure antagonists such as ICI-182,780 (fulvestrant) are effective alternatives to tamoxifen (an ER antagonist/weak partial agonist) in the treatment of postmenopausal, receptor-positive human breast cancers. Structurally, these pure antagonists contain the basic core structure of 17beta-estradiol (E(2)) with a long side chain ...
Xiang-Rong, Jiang, J Walter, Sowell, Bao Ting, Zhu   +2 more
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Lipoidal Derivative of Estradiol: The Biosynthesis of a Nonpolar Estrogen Metabolite*

Endocrinology, 1981
The incubation of estradiol with human breast tumors as well as several estrogen-responsive tissues of the rat, including dimethylbenzanthracene-induced mammary tumors, leads to the formation of a nonpolar metabolite. This compound has been called a lipoidal derivative of estradiol because of its nonpolar characteristics and because it is converted ...
F, Schatz, R B, Hochberg
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18 F–labeled estradiol derivative for targeting estrogen receptor-expressing breast cancer

Nuclear Medicine and Biology, 2018
A novel radiotracer 1‑(2‑(2‑(2‑[18F]fluoroethoxy)ethoxy)ethyl)‑1H‑1,2,3‑triazole‑estradiol ([18F]FETE) was successfully synthesized, characterized and evaluated in mice for estrogen receptor (ER)-positive breast cancer targeting with positron emission tomography (PET) imaging.The tosylate precursor 3 was radiolabeled with 18F and then reacted with 17α ...
Duo, Xu, Rongqiang, Zhuang, Linyi, You, Zhide, Guo, Xiangyu, Wang, Chenyu, Peng, Deliang, Zhang, Pu, Zhang, Hua, Wu, Weimin, Pan, Xianzhong, Zhang   +10 more
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17-alpha-substituted derivatives of estradiol with wound-healing activity

2006
The invention relates to 17alpha -(5-hydroxy-C5-hydrocarbyl)-1,3,5(10)-estratrien-3,17beta -diol derivatives having cicatrising activity, preferably for topical use on wounds, without significant systemic effects, and to pharmaceutical compositions containing them.
ASHCROFT G, BRUFANI M, CECCACCI, FRANCESCA, FARINA P. M, FILOCAMO, Luigi, GAROFALO B, JOUDIOUX R, MAGGI A, MARINI BETTOLO, Rinaldo, MIGNECO, Luisa Maria   +9 more
openaire   +4 more sources

Estradiol activation of human colon carcinoma-derived Caco-2 cell growth.

Cancer research, 1996
This is the first report on estrogen-dependent growth of human-derived colon carcinoma cells. Under selected conditions, growth of subconfluent Caco-2 cells is triggered by estradiol. Cell growth is estradiol concentration dependent, with maximal effect occurring at about 0.4 nM.
DI DOMENICO, Marina, CASTORIA, Gabriella, BILANCIO, Antonio, MIGLIACCIO, Antimo, Auricchio F.   +4 more
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