Results 71 to 80 of about 232,511 (342)

Co‐overexpression of the caloric restriction‐induced mitochondrial factors PGC‐1α and MIPEP upregulates Phospho1 expression in adipocytes

FEBS Open Bio, EarlyView.
Caloric restriction that extends lifespan induces the expression of PGC‐1α and MIPEP in white adipose tissue. In this study, co‐overexpression of Pgc‐1α and Mipep upregulated the gene expression of PHOSPHO1. These findings provide new insights into mitochondria‐related mechanisms underlying the effects of caloric restriction in adipocytes.
Mamiko Ishimatsu, Kanari Taki, Asuka Hayami, Komachi Kato, Yuka Nozaki, Yuhei Mizunoe, Takumi Narita, Ryoichi Mori, Yoshikazu Higami, Masaki Kobayashi   +9 more
wiley   +1 more source

Immunolocalization of steroidogenic enzymes in the vaginal mucous of Galea spixii during the estrous cycle. [PDF]

, 2017
BackgroundThe synthesis of sex steroids is controlled by several enzymes such as17α-hydroxylase cytochrome P450 (P450c17) catalyzing androgen synthesis and aromatase cytochrome P450 (P450arom) catalyzing estrogen synthesis, both of which must complex ...
Assis Neto, Antônio Chaves de, Conley, Alan James, de Oliveira, Moacir Franco, Dos Santos, Amilton Cesar, Oliveira, Gleidson Benevides, Viana, Diego Carvalho   +5 more
core   +1 more source

Measured body size and serum estrogen metabolism in postmenopausal women: the Ghana Breast Health Study

Breast Cancer Research, 2022
Background Several anthropometric measures have been associated with hormone-related cancers, and it has been shown that estrogen metabolism in postmenopausal women plays an important role in these relationships.
Ashley M. Geczik, Roni T. Falk, Xia Xu, Daniel Ansong, Joel Yarney, Beatrice Wiafe-Addai, Lawrence Edusei, Florence Dedey, Verna Vanderpuye, Nicholas Titiloye, Ernest Adjei, Francis Aitpillah, Ernest Osei-Bonsu, Joseph Oppong, Richard Biritwum, Kofi Nyarko, Seth Wiafe, Baffour Awuah, Joe-Nat Clegg-Lamptey, Thomas U. Ahearn, Jonine Figueroa, Montserrat Garcia-Closas, Louise A. Brinton, Britton Trabert   +23 more
doaj   +1 more source

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

Oral ethinylestradiol in castration resistent prostate cancer: 10 year experience [PDF]

, 2015
To describe our 10-year experience with the use of oral ethinylestradiol in the treatment of metastatic castration-resistant prostate cancer. METHODS: From February 2000 to April 2010, 116 patients with a metastatic castration-resistant prostate cancer
Aggarwal, Beer, Bonkhoff, Bono, Chadha, Corey, Di Silverio, Gasent Blesa, Izumi, Kitahara, Limonta, Montgomery, Shamash, Stein, Takezawa, Tannock, Wilkins   +16 more
core   +1 more source

Estrogens regulate the hepatic effects of Growth Hormone, a hormonal interplay with multiple fates

Frontiers in Endocrinology, 2013
The liver responds to estrogens and GH which are critical regulators of body growth, gender-related hepatic functions, and intermediate metabolism. The effects of estrogens on liver can be direct, through the direct actions of hepatic ER, or indirect ...
Leandro eFernandez-Perez, Carlos eBorja-Guerra, Juan Carlos eDiaz-Chico, Amilcar eFlores-Morales   +3 more
doaj   +1 more source

A Network Meta‐Analysis of Efficacy of Different Interventions in the Prevention of Postoperative Intrauterine Adhesions

Clinical and Translational Science, 2020
This network meta‐analysis was conducted to compare the efficacy of six interventions, including anti‐blocking agents, intrauterine contraceptive devices (IUDs), estrogens, intrauterine balloon, Foley catheter, and amnion graft for the prevention of ...
Qian Xiong, Tiansong Zhang, Shujun Su
doaj   +1 more source

Cognitive Resilience in Apolipoprotein ε4 Carrier Women Predicted by Neuron‐Derived Extracellular Vesicles

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The Apolipoprotein (APOE) ε4 allele is the strongest genetic risk factor for late‐onset Alzheimer's disease (AD); however, many ε4 carriers remain cognitively intact into old age. Leveraging plasma neuron‐derived extracellular vesicles (NDEVs), we sought to identify biomarkers of cognitive resilience and their interplay with APOE ...
Apostolos Manolopoulos, Maja Mustapic, Carlos Nogueras‐Ortiz, Francheska Delgado‐Peraza, Krishna A. Pucha, Pamela J. Yao, Joseph Blommer, Michael P. Vreones, William York, De' Larrian Knight, Stephen R. Rapp, Aladdin H. Shadyab, JoAnn E. Manson, Ramon Casanova, Robert B. Wallace, Luigi Ferrucci, Susan M. Resnick, Dimitrios Kapogiannis   +17 more
wiley   +1 more source

The serotonin transporter promotes a pathological estrogen metabolic pathway in pulmonary hypertension via cytochrome P450 1B1 pulmonary circulation [PDF]

, 2016
Pulmonary arterial hypertension (PAH) is a devastating vasculopathy that predominates in women and has been associated with dysregulated estrogen and serotonin signaling. Overexpression of the serotonin transporter (SERT+) in mice results in an estrogen-
Anagnostopoulou, Aikaterini, Dean, Afshan, Hood, Katie, Johansen, Anne Katrine Z., Loughlin, Lynn, MacLean, Margaret R., Morecroft, Ian, Nilsen, Margaret, Touyz, Rhian M., White, Kevin   +9 more
core   +1 more source

The Influence of Estrogens on the Biological and Therapeutic Actions of Growth Hormone in the Liver

Pharmaceuticals, 2012
GH is main regulator of body growth and composition, somatic development, intermediate metabolism and gender-dependent dimorphism in mammals. The liver is a direct target of estrogens because it expresses estrogen receptors which are connected with ...
Leandro Fernández-Pérez, Nicolás Díaz-Chico, Roberto Jiménez-Monzón, Carlos Mateos-Díaz, Borja Guerra, Mercedes de Mirecki-Garrido, Juan C. Díaz-Chico   +6 more
doaj   +1 more source