Results 71 to 80 of about 239,432 (343)
Frontiers in Endocrinology, 2023 BackgroundAbnormally changed steroid hormones during pregnancy are closely related to the pathological process of gestational diabetes mellitus (GDM). Our aim was to systematically profile the metabolic alteration of circulating steroid hormones in GDM ...
Na Yang +10 more
doaj +1 more source
Arthritis Care &Research, Accepted Article.Objective This study aimed to characterize the pharmacokinetics, pharmacodynamics, safety, and exploratory efficacy of subcutaneous belimumab in pediatric patients with active systemic lupus erythematosus (SLE) receiving standard therapy. Methods This single‐arm, multicenter, open‐label trial (GSK study 200908; NCT04179032) used three‐weight‐band ...
Hermine I. Brunner +14 more
wiley +1 more source
Química Nova, 2012 The present research aimed to study the parameters that affect the determination of estrogens in sewage upon the use of SPE and determination by using gas chromatography mass spectrometry (GC/MS).
Germana de Paiva Pessoa +4 more
doaj +1 more source
A–C Estrogens as Potent and Selective Estrogen Receptor-Beta Agonists (SERBAs) to Enhance Memory Consolidation under Low-Estrogen Conditions [PDF]
, 2018 Estrogen receptor-beta (ERβ) is a drug target for memory consolidation in postmenopausal women. Herein is reported a series of potent and selective ERβ agonists (SERBAs) with in vivo efficacy that are A–C estrogens, lacking the B and D estrogen rings ...
Donaldson, William A. +12 more
core +4 more sources
3D Multicellular Scaffold Based Model for Advancing Bone Disorder Research
Advanced Functional Materials, EarlyView.A scalable 3D multicellular in vitro bone model engineered by integrating osteoblasts, osteoclasts, and endothelial cells on biodegradable scaffolds. The system recapitulates key features of human bone remodeling and disease pathology. As a proof of concept, the model mimics osteogenesis imperfecta, demonstrating its potential as a physiologically ...
Gali Guterman‐Ram +5 more
wiley +1 more source
Data in Brief, 2019 Analysis of catechol estrogens (2 & 4 hydroxy-estrone and estradiol) has proven troublesome by liquid chromatography tandem mass spectrometry due to their low concentrations, short half-lives and temperature-labile nature.
Nina Denver +6 more
doaj +1 more source
Advanced Functional Materials, EarlyView.A flow‐through electrochemical membrane reactor equipped with a carbon nanotube membrane eliminates the mass transfer limitation, achieving removals >97.5% for steroid hormone (SH) micropollutants through electrochemical adsorption and degradation, over a broad initial concentration varying from 50 to 106 ng L−1.
Siqi Liu +2 more
wiley +1 more source
Estrogen, estrogen-like molecules and autoimmune diseases
Autoimmunity Reviews, 2020 In western countries, the slope of autoimmune disease (AD) incidence is increasing and affects 5-8% of the population. Mainly prevalent in women, these pathologies are due to thymic tolerance processes breakdown. The female sex hormone, estrogen, is involved in this AD female susceptibility.
Merrheim, Judith +6 more
openaire +3 more sources
Advanced Functional Materials, EarlyView.A multifunctional nanodiamond platform enables pH‐triggered Diazoxide (DZX) delivery and quantum sensing of subcellular radical dynamics in triple‐negative breast cancer cells. Diamond relaxometry revealed reduced lysosomal radicals during DZX‐induced mitochondrial radical elevation, providing insights into redox modulation and organelle‐ resolved ...
Kaiqui Wu +8 more
wiley +1 more source
The Influence of Estrogens on the Biological and Therapeutic Actions of Growth Hormone in the Liver
Pharmaceuticals, 2012 GH is main regulator of body growth and composition, somatic development, intermediate metabolism and gender-dependent dimorphism in mammals. The liver is a direct target of estrogens because it expresses estrogen receptors which are connected with ...
Leandro Fernández-Pérez +6 more
doaj +1 more source