Results 111 to 120 of about 68,328 (223)

Inflammation in Idiopathic Intracranial Hypertension: An Immunometabolic Mechanistic Framework and Clinical Implications

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
Systemic metabolic dysfunction and comorbidities may act as upstream modulators converging on inflammatory activation, which is closely intertwined with excessive CSF production and impaired clearance, potentially contributing to sustained ICP elevation.
Guangyu Han   +5 more
wiley   +1 more source

Multi‐Target Mechanisms of Whey Protein Against NAFLD: Integrating Bile Acid Metabolism, Gut Microbiota and Hepatic Inflammation

open access: yesFood Science &Nutrition, Volume 14, Issue 3, March 2026.
Whey protein (WP) alleviates high‐fat diet (HFD)‐induced nonalcoholic fatty liver disease (NAFLD) through a tripartite mechanism targeting the gut‐liver axis. (1) Gut Microbiota Modulation: WP restores intestinal flora homeostasis by enriching beneficial taxa (e.g., Lactobacillus) and increasing the production of short‐chain fatty acids (SCFAs).
Dongjin Xu   +12 more
wiley   +1 more source

Residual Chemical Shift Anisotropies in the Structure Determination of Small Molecules

open access: yesMagnetic Resonance in Chemistry, Volume 64, Issue 3, Page 286-311, March 2026.
Plasma neutrophil elastase(ELANE) was markedly elevated in patients with alcohol use disorder, indicating a dysregulated protease‐antiprotease inflammatory balance characterised by decreased SERPINA3. ELANE showed excellent diagnostic specificity(AUC = 0.8683), supporting its potential utility as a neuroinflammatory biomarker for AUD.
Nilamoni Nath   +3 more
wiley   +1 more source

Immunostaining of P450c17, Aromatase and Oestrogen Receptor Alpha in Germ and Somatic Cells During Gonadal Development in Greater Rhea

open access: yesAnatomia, Histologia, Embryologia, Volume 55, Issue 2, March 2026.
ABSTRACT The greater rhea (Rhea americana), the largest bird species in South America, has significant economic value due to its meat, eggs, leather, feathers and oil. However, its lack of external sexual dimorphism poses challenges for reproductive management and breeding programmes.
Marilú Cristofoli   +7 more
wiley   +1 more source

INSL3 Expression in Leydig Cells is a Biomarker for Immunocastration in Boars: Transcriptional Evidence

open access: yesAndrology, Volume 14, Issue 3, Page 782-795, March 2026.
ABSTRACT Background Study aimed to obtain insights into physiological responses to immunocastration in pubertal boars by evaluating effects of alternative vaccination protocols and identifying a reliable immunocastration biomarker. Objectives It was hypothesized that the timing of gonadotropin‐releasing hormone (GnRH) suppression by immunocastration ...
Nina Batorek Lukač   +6 more
wiley   +1 more source

A regioselectivity switch in Pd-catalyzed hydroallylation of alkynes. [PDF]

open access: yes, 2019
By exploiting the reactivity of a vinyl-Pd species, we control the regioselectivity in hydroallylation of alkynes under Pd-hydride catalysis. A monophosphine ligand and carboxylic acid combination promotes 1,5-dienes through a pathway involving ...
Chen, Qing-An   +5 more
core  

Impact of Efavirenz on Heme Protein Induction and Biomarkers: Insights From In Vitro Experiments and a Clinical Study

open access: yesClinical and Translational Science, Volume 19, Issue 3, March 2026.
ABSTRACT Coproporphyrin I (CPI) is increasingly recognized as a reliable endogenous biomarker for hepatic OATP1B transporters. However, confounding mechanisms such as increased heme biosynthesis driven by induction of CYP enzymes, which are hemoproteins, may affect CPI levels independently of OATP1B1 inhibition. The aim of this study was to investigate
Leila Potzel   +5 more
wiley   +1 more source

Sex Matters: Hormonal and Chromosomal Determinants of Autoimmunity and Anti‐Cancer Immunity Across the Lifespan

open access: yesImmunological Reviews, Volume 338, Issue 1, March 2026.
ABSTRACT Sex plays a key role in shaping both anti‐cancer immunity and autoimmunity. Biological factors underlying sexual dimorphism have now been identified in multiple aspects of anti‐cancer immunity and autoimmunity. These factors include sex differences in hormone levels, chromosome complement, and expression of the long non‐coding RNA XIST.
Christian G. Bustillos   +4 more
wiley   +1 more source

MONITORING OF PROGESTERONE AND ESTRONE FECAL METABOLITES THROUGHOUT GESTATION IN EWES

open access: yesCiência Animal Brasileira, 2019
The aim of this study was to monitor the progesterone and fecal estrone metabolites throughout gestation in ewes correlating with the serum levels of these steroid hormones. Therefore, fecal and serum samples were collected from 5 weeks before mating and
Rodrigo de Souza Amaral   +4 more
doaj  

Sex Differences in Response to Viral Vector Vaccines—Implications for Future Vaccine Design

open access: yesImmunological Reviews, Volume 338, Issue 1, March 2026.
ABSTRACT Vaccination represents one of the most impactful public health achievements, preventing 3.5 to 5 million deaths annually according to estimates of the World Health Organization. Yet, recent outbreaks of emerging and reemerging infectious diseases highlight the need for rapid and strategic vaccine development using vaccine platforms ...
Ilka Grewe   +2 more
wiley   +1 more source

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