Results 71 to 80 of about 64,198 (266)
Cytochrome P450 1A1 influences obesity‐induced pulmonary hypertension
British Journal of Pharmacology, EarlyView.Background and Purpose The contribution of obesity to pulmonary arterial hypertension (PAH) pathophysiology remains poorly understood. Adipose tissue synthesises estrogens via cytochrome P450 (CYP) 19A1 (aromatase), whereas circulating estrogens are metabolised in the lung by CYP1A1.
Joshua P. Dignam +12 more
wiley +1 more source
Nutrition Journal, 2004 Background We have demonstrated that moderate alcohol consumption (15 g/d, 30 g/d) for 8 weeks resulted in significantly increased levels of serum estrone sulfate and DHEAS in 51 postmenopausal women in a randomized, placebo-controlled trial.
Albanes Demetrius +10 more
doaj +1 more source
Steroid Hormones Are Potent and Putatively Endogenous Activators of Human Bitter Taste Receptors
Annals of the New York Academy of Sciences, EarlyView.Human bitter taste receptors are not only involved in sensing tastants within the oral cavity but also play crucial roles in internal tissues of the body. The current report identifies numerous structurally and functionally diverse steroid hormones as activators of the two human bitter taste receptors, TAS2R14 and TAS2R46.
Tatjana Lang +4 more
wiley +1 more source
Bifunctional Aziridines from Photochemically Generated FSO2NH2 for SuFEx Diversification of Alkenes
Angewandte Chemie, Volume 138, Issue 2, 9 January 2026.Photochemically generated FSO2NH2 serves as a safe, practical nitrene precursor for Rh‐catalyzed aziridination of alkenes, granting access to previously inaccessible fluorosulfonyl aziridines. These bifunctional electrophiles merge aziridine ring strain with SuFEx reactivity to provide a modular platform toward aliphatic sulfamoyl fluoride derivatives ...
Avinash Choudhury +3 more
wiley +2 more sources
Experimental Physiology, EarlyView.Abstract This narrative review highlights the impact of exercise on vascular health in females over the lifespan with an emphasis on puberty, pregnancy and menopause. These events encompass substantial changes in sex hormone levels, particularly oestrogens and progesterone.
Kathleen B. Miller +2 more
wiley +1 more source
Immunological Reviews, Volume 338, Issue 1, March 2026.ABSTRACT Sex plays a key role in shaping both anti‐cancer immunity and autoimmunity. Biological factors underlying sexual dimorphism have now been identified in multiple aspects of anti‐cancer immunity and autoimmunity. These factors include sex differences in hormone levels, chromosome complement, and expression of the long non‐coding RNA XIST.
Christian G. Bustillos +4 more
wiley +1 more source
Sex Differences in Response to Viral Vector Vaccines—Implications for Future Vaccine Design
Immunological Reviews, Volume 338, Issue 1, March 2026.ABSTRACT Vaccination represents one of the most impactful public health achievements, preventing 3.5 to 5 million deaths annually according to estimates of the World Health Organization. Yet, recent outbreaks of emerging and reemerging infectious diseases highlight the need for rapid and strategic vaccine development using vaccine platforms ...
Ilka Grewe +2 more
wiley +1 more source
In Vitro and Clinical Evaluation of Potential Interactions of Bemnifosbuvir with Drug Transporters
The Journal of Clinical Pharmacology, Volume 66, Issue 2, February 2026.Abstract Bemnifosbuvir is a novel oral guanosine nucleotide prodrug candidate for the treatment of chronic hepatitis C virus infection. Potential drug–drug interactions (DDIs) of bemnifosbuvir as a substrate or perpetrator with regard to ATP‐binding cassette (ABC) and solute carrier (SLC) transporters were evaluated in vitro and in clinical studies ...
Xiao‐Jian Zhou +9 more
wiley +1 more source
The use of Xuanbai Chengqi decoction on monkeypox disease through the estrone-target AR interaction [PDF]
, 2023 Yanqi Jiao, Chengcheng Shi, Yao Sun
openalex +1 more source