Results 191 to 200 of about 61,834 (330)

Establishing a Quantitative Framework for Combined Oral Contraceptives: Evaluating the Impact of Drug–Drug Interactions on Exposure and Clinical (Surrogate) Efficacy Endpoints

The Journal of Clinical Pharmacology, Volume 65, Issue 12, Page 1855-1863, December 2025.
Abstract According to the FDA Guidance for Industry on Clinical Drug Interaction (DDI) Studies with Combined Oral Contraceptives (COCs), sponsors are expected to conduct dedicated clinical DDI studies if in vitro findings suggest weak or moderate CYP3A induction, while concomitant use of COCs with strong inducers should be avoided. The guidance further
Dain Chun, Huili Chen, Brian Cicali, Serge Guzy, Joachim Hoechel, Tianze Jiao, Valvanera Vozmediano, Stephan Schmidt   +7 more
wiley   +1 more source

Ovarian Aging: Mechanisms, Age‐Related Disorders, and Therapeutic Interventions

MedComm, Volume 6, Issue 12, December 2025.
A comprehensive overview of the molecular mechanisms underlying ovarian aging, its association with age‐related diseases, and potential therapeutic interventions. Ovarian aging involves DNA damage, mitochondrial dysfunction, oxidative stress, telomere attrition, and follicular depletion, driving age‐related infertility, menopause, and multiple systemic
Xingyu Liu, Yuanqu Zhao, Yanzhi Feng, Shixuan Wang, Jinjin Zhang   +4 more
wiley   +1 more source

Insulin binding characteristics in canine muscle tissue: effects of the estrous cycle phases [PDF]

, 2016
Álan Gomes Pöppl, Sandra Costa Valle, Félix Hilário Díaz González, Luiz Carlos Kucharski, Roselis S.M. da Silva   +4 more
openalex   +1 more source

Elucidation of the effects of caffeine consumption on estrous cycle, hematology, and lipid profile of female Wistar rats. [PDF]

Sci Rep
Ogunwole E, Ogunmiluyi OE, Adesida AO, Akinwa PO, Akinya AO, Fakeye OA, Oyetoyan BO.   +6 more
europepmc   +1 more source

Fluorometric determination of plasma progesterone during estrous cycle in the cow

, 1974
Ikuo Domeki, Tatsuo Nakahara, Makoto YAMAUCHI   +2 more
openalex   +2 more sources

Influence of estrogen, progesterone and estrous cycle on γ‐glutamyltranspeptidase of rat endometrium [PDF]

, 1982
U. Tarachand, Jacob Eapen
openalex   +1 more source

Efferocytosis in Health and Disease

MedComm, Volume 6, Issue 12, December 2025.
Efferocytosis in health and disease. Efferocytosis integrates apoptotic cell recognition, engulfment, digestion, and reprogramming to link cell clearance with tissue repair. Molecular checkpoints balance “eat‐me” signals such as phosphatidylserine against inhibitory “don't‐eat‐me” cues like CD47, while TAM receptors, scavenger receptors, and integrins ...
Chaofu Li, Yukun Yang, Fating Zhou, Qiuyan Jiang, Yingying Jiang, Xuanjie Huang, Yiqiong Zhang, Zhengmeng Ye, Gang Xu, Guoying Kao, Ke Zhou, Fan Yang, Jun Xiao, Wei Wu, Chuanwei Li   +14 more
wiley   +1 more source

Advanced Multiscale Attention Network for Estrous Cycle Stage Identification from Rat Vaginal Cytology. [PDF]

Biology (Basel)
Wang Q, Zhao Y, Pu X.
europepmc   +1 more source

Stable Density and Dynamics of Dendritic Spines of Cortical Neurons Across the Estrous Cycle While Expressing Differential Levels of Sensory-Evoked Plasticity [PDF]

, 2018
Bailin H. Alexander, Heather M. Barnes, Emma H. Trimmer, Andrew M. Davidson, Benard O. Ogola, Sarah H. Lindsey, Ricardo Mostany   +6 more
openalex   +1 more source

Hormones reflect the impacts of reproductive rest on subsequent pregnancy in a marine predator

Functional Ecology, Volume 39, Issue 12, Page 3417-3433, December 2025.
Read the free Plain Language Summary for this article on the Journal blog. Abstract After reaching sexual maturity, iteroparous female vertebrates may intermittently skip producing offspring, effectively taking a year of reproductive rest. This may confer benefits to lifetime fitness by enhancing future reproductive success.
Amy L. Kirkham, Michelle R. Shero, Gregg P. Adams, Robert McCorkell, Donald Thompson Jr., Roxanne S. Beltran, Shannon Atkinson, Jennifer M. Burns   +7 more
wiley   +1 more source