Results 31 to 40 of about 26,148 (242)

Calcitonin Gene‐Related Peptide (CGRP)‐Expressing Neurons in the External Lateral Parabrachial Area Regulate Pain‐Induced Sleep Disturbances

Advanced Science, EarlyView.
Lynch et al., identified novel targets on the wake‐promoting pathways that can effectively treat pain‐induced sleep disturbances. The authors demonstrated that Calcitonin gene‐related peptide‐expressing neurons (CGRP) in the external lateral parabrachial nucleus (PBelCGRP) serve as the primary relay node for pain stimuli that cause sleep disruption ...
Nicole Lynch, Roberto De Luca, Richard L Spinieli, Enrico Rillosi, Renner C Thomas, Samuel Sailesh, Nishta Gangeddula, Janayna D Lima, Sathyajit S Bandaru, Elda Arrigoni, Agustin Melo‐Carrillo, Rami Burstein, Stephen Thankachan, Satvinder Kaur   +13 more
wiley   +1 more source

The murine female intestinal microbiota does not shift throughout the estrous cycle.

PLoS ONE, 2018
Pregnancy is accompanied by maternal physiological adaptations including metabolic, endocrine, immune, cardiovascular, skeletomuscular and neurological modifications that facilitate fetal and placental growth and development.
Jessica G Wallace, Ryan H Potts, Jake C Szamosi, Michael G Surette, Deborah M Sloboda   +4 more
doaj   +1 more source

FABP4 as a Mediator of Lipid Metabolism and Pregnant Uterine Dysfunction in Obesity

Advanced Science, EarlyView.
Obesity during late pregnancy contributes to uterine smooth muscle dysfunction, but the underlying mechanisms are unclear. This study identifies fatty acid binding protein 4 (FABP4) as a key player in the process, mediating excessive fatty acid uptake, lipid accumulation, and mitochondrial dysfunction in myometrial cells. FABP4 could be a novel uterine
Xuan Li, Huihui Yu, Ruixian Tian, Xingxing Wang, Ting Xing, Chenyi Xu, Tengteng Li, Xue Du, Qianqian Cui, Biao Yu, Yunxia Cao, Zongzhi Yin   +11 more
wiley   +1 more source

RSPO2 Coordinates with GDF9:BMP15 Heterodimers to Promote Granulosa Cell and Oocyte Development in Mice

Advanced Science, EarlyView.
RSPO2 and GDF9:BMP15 heterodimers—core components of oocyte‐secreted factors (OSFs)—coordinate to shape the molecular architecture of preantral granulosa cells via gene‐specific synergistic and antagonistic regulation, mediated through CTNNB1–SMAD2 signaling crosstalk.
Yingmei Wang, Hongjiang Li, Liji You, Shuhui Wang, Jinglei Bie, Ziyang Su, Lanying Shi, You‐Qiang Su   +7 more
wiley   +1 more source

Digital workflows for pathological assessment of rat estrous cycle stage using images of uterine horn and vaginal tissue

Journal of Pathology Informatics, 2022
Assessment of the estrous cycle of mature female mammals is an important component of verifying the efficacy and safety of drug candidates. The common pathological approach of relying on expert observation has several drawbacks, including laborious work ...
Shinichi Onishi, Riku Egami, Yuya Nakamura, Yoshinobu Nagashima, Kaori Nishihara, Saori Matsuo, Atsuko Murai, Shuji Hayashi, Yoshifumi Uesumi, Atsuhiko Kato, Hiroyuki Tsunoda, Masaki Yamazaki, Hideaki Mizuno   +12 more
doaj  

Plasticity of intrinsic excitability across the estrous cycle in hypothalamic CRH neurons

Scientific Reports, 2021
Stress responses are highly plastic and vary across physiological states. The female estrous cycle is associated with a number of physiological changes including changes in stress responses, however, the mechanisms driving these changes are poorly ...
Emmet M. Power, Karl J. Iremonger
doaj   +1 more source

A companion to the preclinical common data elements for rigor, reproducibility and transparency in basic and translational epilepsy research. A report of the TASK3‐WG1A: Pharmacology Working Group of the ILAE/AES Joint Translational Task Force

Epilepsia Open, EarlyView.
Abstract Rigorous and transparent procedures in preclinical epilepsy research studies are important to permit assessing the reproducibility of their findings and derisk their translation into the clinic. The General Pharmacology Working Group of the ILAE/AES Task Force (TASK3‐WG1A) developed common data elements (CDEs) addressing rigor and transparency
Brian D. Klein, Lauren Harte‐Hargrove, Wenzhu Mowrey, Aristea S. Galanopoulou, Cameron S. Metcalf, Lisa Coles, Patrick A. Forcelli, Anna‐Maria Katsarou, Rudiger Koehling, Karine Leclercq, Heidrun Potschka, TASK3‐WG1A working group   +11 more
wiley   +1 more source

Hippocampal GABAA Receptor and Pain Sensitivity during Estrous Cycle in the Rat [PDF]

Iranian Journal of Medical Sciences, 2011
Background: Estradiol and progesterone as well as hippocampal GABAA receptors are believed to play a role in the modulation of pain. The aim of present study was to investigate the effect of intrahippocampal injections of GABAA receptor agonist (muscimol)
Mahnaz Taherianfard, Mahnaz Mosavi
doaj  

Evaluation of anti-Mullerian hormone, antral follicle count and progesterone concentration during estrous cycle in Murrah buffaloes

Indian Journal of Animal Sciences, 2019
An experiment was conducted to study the anti-Mullerian hormone (AMH) concentration, antral follicle count (AFC) and progesterone (P4) concentration during estrous cycle in Murrah buffaloes. Seven animals of 5–10 years were selected for the study.
P M KEKAN, S D INGOLE, A S NAGVEKAR, S V BHARUCHA, S D KHARDE, D P KADAM, C N GALDHAR, P S MASARE, S G DESHMUKH   +8 more
doaj   +1 more source

Chronic Stress Detrimentally Affects In Vivo Maturation in Rat Oocytes and Oocyte Viability at All Phases of the Estrous Cycle

Animals, 2021
Background: Stress has been considered as one of the causes of decreased reproductive function in women. However, direct evidence of the effect of chronic stress on oocytes depending on estrous cycle phases is limited.
Fahiel Casillas, Miguel Betancourt, Lizbeth Juárez-Rojas, Yvonne Ducolomb, Alma López, Alejandra Ávila-Quintero, Jimena Zamora, Mohammad Mehdi Ommati, Socorro Retana-Márquez   +8 more
doaj   +1 more source