Results 41 to 50 of about 35,836 (303)

CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction

Advanced Science, EarlyView.
CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma, Jiali Jia, Juncong Lan, Jing Wang, Dan Rao, Lanlan Rao, Weibin Zhang, Dongpeng Wu, Jie Zhang, Gang Wang, Baohua Liu, Ying Ao, Zimei Wang   +12 more
wiley   +1 more source

Estrous cycle after 3 months HFD treatment.

, 2015
Estrous cycle after 3 months HFD treatment.
Abigail R. Dowling (301031), Kaitlyn M. Garcia (735441), Carol F. Elias (386291), Hoangha Dao (735439), Latrice D. Faulkner (735443), Xiaoliang Qiu (487436), Alisha Sangal (735442), Jennifer W. Hill (301036), Amelia Heston (735440), Mengjie Wang (436531), Scott C. Molitor (735444)   +10 more
core   +1 more source

Real‐Time in Vivo Monitoring of Circulating Endometrial Cells: Uncovering Systemic Dissemination and Temporal Fluctuations in Endometriosis

Advanced Science, EarlyView.
A dual‐color pseudo‐menstrual mouse model enables real‐time tracing of circulating endometrial cells (CECs) from uterine and ectopic sources. The study reveals menstrual‐phase‐dependent, burst‐like CEC release, distinct postoperative behaviors of different CEC origins, and a potential association with prolactin fluctuations, providing an in vivo ...
Shang Wang, Chenyu Hou, Buyun Li, Hongyan Cheng, Xue Ye, Honglan Zhu, Yanmin Li, Rui Chen, Sihan Dong, Yi Li, Huiping Liu, Chen Zhang, Rui Zhang, Hongyi Hou, Xunbin Wei, Xiaohong Chang   +15 more
wiley   +1 more source

The murine female intestinal microbiota does not shift throughout the estrous cycle.

PLoS ONE, 2018
Pregnancy is accompanied by maternal physiological adaptations including metabolic, endocrine, immune, cardiovascular, skeletomuscular and neurological modifications that facilitate fetal and placental growth and development.
Jessica G Wallace, Ryan H Potts, Jake C Szamosi, Michael G Surette, Deborah M Sloboda   +4 more
doaj   +1 more source

Determination of the rat estrous cycle vased on EfficientNet. [PDF]

Front Vet Sci
In the field of biomedical research, rats are widely used as experimental animals due to their short gestation period and strong reproductive ability. Accurate monitoring of the estrous cycle is crucial for the success of experiments. Traditional methods
Pu X, Liu L, Zhou Y, Xu Z.
europepmc   +2 more sources

Motivated behavior and the estrous cycle in rats [PDF]

Psychoneuroendocrinology, 1981
Abstract (1) The estrous cycle in the rat may be used to study recurrent changes in motor behaviors and motivation which are strongly related to cyclic hormonal and CNS changes. (2) The peak in motivated behaviors occurs during a sharply defined period on the night between proestrus and estrus and is evident in facilitated wheel-running, lordosis ...
Steiner, Meir, Katz, Richard J., Baldrighi, Giulio, Carroll, Bernard J.   +3 more
openaire   +3 more sources

A preclinical mouse model mimicking the ovarian cancer‐induced estrogen deficiency‐depression axis

Animal Models and Experimental Medicine, EarlyView.
A preclinical mouse model of ovarian cancer–related depression was developed by combining intraperitoneal tumor cell injection, ovariectomy, and chronic restraint stress. The model replicates key clinical features including estrogen deficiency, depressive‐like behaviors, and tumor progression, and provides a reliable tool for studying the endocrine ...
Jiamin Liu, Yafei Yang, Chunxi Liu, Danting Wen, Tingyu Zhao, Ping Xie, Jing Xiao   +6 more
wiley   +1 more source

A novel mouse model of endometriosis: Simulating the recurrent hemorrhagic microenvironment of clinical lesions

Animal Models and Experimental Medicine, EarlyView.
To address the limitations of existing models, this study innovatively established a mouse model of endometriosis (EMs) capable of mimicking cyclic bleeding. Our results confirmed that this model recapitulates the complete pathological progression from ectopic lesion establishment to systemic responses, exhibiting superior clinical relevance compared ...
Yu Zhuang, Yan Zan, Tiantian Ma, Xiaoquan Huang, Junwei Li, Liangjun Xia, Yuping Sa, Youbing Xia   +7 more
wiley   +1 more source

Estrous cycle alteration.

, 2014
Estrous cycle determined according to the observation of the cell population of vaginal washes was daily followed on mice in standard conditions (CT), or separated and submitted to food access restriction (SBA) from day 0 to day 70, followed by 20 days ...
Nicole Bellefontaine (608599), Isabelle Legroux-Gérot (608600), Odile Broux (608602), Mathieu Méquinion (608596), Damien Leterme (608597), Odile Viltart (113066), Virginie Tolle (113086), Stéphanie Lucas (88200), Pierre Hardouin (608601), Christophe Chauveau (608603), Olfa Ghali (608598), Philippe Zizzari (113063), Sara Zgheib (608595)   +12 more
core   +1 more source

Canine brachycephalic obstructive airway syndrome as a model for studying the effects of obstructive sleep apnea during pregnancy

Animal Models and Experimental Medicine, EarlyView.
We observed a negative effect of brachycephalic obstructive airway syndrome (BOAS) in a staggered manner based on the severity of the condition on respiratory and cardiac patterns, glycemia, acid–base balance, fetal growth, and uterine artery hemodynamics, thus requiring adaptations within the fetal–placental unit. Severely affected bitches had uterine
Roberto Rodrigues da Rosa Filho, Thayná Pantoja Gardés, Maíra Morales Brito, Leticia Lima de Almeida, Camila Infantosi Vannucchi   +4 more
wiley   +1 more source