Results 221 to 230 of about 95,297 (317)

Establishing a Quantitative Framework for Combined Oral Contraceptives: Evaluating the Impact of Drug–Drug Interactions on Exposure and Clinical (Surrogate) Efficacy Endpoints

open access: yesThe Journal of Clinical Pharmacology, Volume 65, Issue 12, Page 1855-1863, December 2025.
Abstract According to the FDA Guidance for Industry on Clinical Drug Interaction (DDI) Studies with Combined Oral Contraceptives (COCs), sponsors are expected to conduct dedicated clinical DDI studies if in vitro findings suggest weak or moderate CYP3A induction, while concomitant use of COCs with strong inducers should be avoided. The guidance further
Dain Chun   +7 more
wiley   +1 more source

Pregnancy and lambing rates following direct transfer of vitrified embryos in field ewes of Bangladesh. [PDF]

open access: yesJ Adv Vet Anim Res
Islam MM   +5 more
europepmc   +1 more source

Ovarian Aging: Mechanisms, Age‐Related Disorders, and Therapeutic Interventions

open access: yesMedComm, Volume 6, Issue 12, December 2025.
A comprehensive overview of the molecular mechanisms underlying ovarian aging, its association with age‐related diseases, and potential therapeutic interventions. Ovarian aging involves DNA damage, mitochondrial dysfunction, oxidative stress, telomere attrition, and follicular depletion, driving age‐related infertility, menopause, and multiple systemic
Xingyu Liu   +4 more
wiley   +1 more source

Efficacy of Two Estrus Synchronization Protocols in Crossbred Gyr Dairy Cows and Their Relationship with Heat Stress in the Peruvian Tropics. [PDF]

open access: yesVet Sci
Vásquez-Tarrillo RW   +8 more
europepmc   +1 more source

A persistent hymen resulting in an open cervix but closed pyometra and pyocolpos in a mixed‐breed female domestic dog

open access: yesVeterinary Record Case Reports, Volume 13, Issue 4, December 2025.
Abstract A rescued mixed‐breed (Africanis type), entire, female dog, approximately 2 years old, with an unknown history, presented with a prominent perineal swelling between the anus and vulva. Ultrasound identified it as a fluid‐filled structure, and an aspirate revealed an exudate consisting of degenerate neutrophils, bacterial cocci and rods.
Taylor June Kruger   +4 more
wiley   +1 more source

Analysis of transcriptome and metabolome characteristics of blood in yaks at different reproductive stages. [PDF]

open access: yesFront Vet Sci
Kang Y   +12 more
europepmc   +1 more source

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