Results 31 to 40 of about 29,178 (233)

A Toolkit for Targeted Neuromodulation of Striatal Direct Pathway Neurons Rescues Parkinsonian Motor Deficits in Mice

Advanced Science, EarlyView.
An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong, Yujing Zhang, Junjiao Zhang, Hanhe Liu, Qiwei Liu, Yanglei Li, Lixin Yang, Lixia Li, Zhongjie Liu, Zhen Yuan, Zhonghua Lu, Yefei Chen, Yuantao Li, Yuwu Jiang, Taian Liu   +14 more
wiley   +1 more source

Integrated Convolution and Attention Enhancement-You Only Look Once: A Lightweight Model for False Estrus and Estrus Detection in Sows Using Small-Target Vulva Detection

Animals
Accurate estrus detection and optimal insemination timing are crucial for improving sow productivity and enhancing farm profitability in intensive pig farming.
Yongpeng Duan, Yazhi Yang, Yue Cao, Xuan Wang, Riliang Cao, Guangying Hu, Zhenyu Liu   +6 more
doaj   +1 more source

Palmitoylation of PSD‐95 Orchestrates Learning‐Dependent Metaplasticity in the Amygdala and Fear Memory

Advanced Science, EarlyView.
This study reveals that fear learning specifically triggers PICK1/DHHC2‐dependent palmitoylation of PSD‐95 in the lateral amygdala. Fear conditioning induces the dissociation of DHHC5 from PSD‐95 and the association of PSD‐95 with DHHC2. DHHC2‐mediated palmitoylation of PSD‐95 is required for synaptic transmission and underlies fear learning–induced ...
Zu‐Cheng Shen, Yu‐Xuan Weng, Zhi‐Xuan Xia, Yue‐Ling Zhao, Qian‐Qian Ding, Si‐Ying Wang, Ting Cao, Xuan‐Ying Chen, Wu‐Cheng Tao, Shen Lin, Zhou Chen, Yi‐Xiao Luo   +11 more
wiley   +1 more source

Real‐Time in Vivo Monitoring of Circulating Endometrial Cells: Uncovering Systemic Dissemination and Temporal Fluctuations in Endometriosis

Advanced Science, EarlyView.
A dual‐color pseudo‐menstrual mouse model enables real‐time tracing of circulating endometrial cells (CECs) from uterine and ectopic sources. The study reveals menstrual‐phase‐dependent, burst‐like CEC release, distinct postoperative behaviors of different CEC origins, and a potential association with prolactin fluctuations, providing an in vivo ...
Shang Wang, Chenyu Hou, Buyun Li, Hongyan Cheng, Xue Ye, Honglan Zhu, Yanmin Li, Rui Chen, Sihan Dong, Yi Li, Huiping Liu, Chen Zhang, Rui Zhang, Hongyi Hou, Xunbin Wei, Xiaohong Chang   +15 more
wiley   +1 more source

Social effects on behaviorally-scored and pedometer-detected estrus in beef cattle

The Journal of Reproduction and Development
The number of cows in estrus often influences estrus behavior; however, the effects of social order are not well documented. This study examined the effects of social order on the expression of behaviorally-scored and pedometer-detected estrus, combined ...
Hiromi KUSAKA, Minoru SAKAGUCHI
doaj   +1 more source

The Efficacy of Seminal Vesicles Extract Administration on Percentage of Estrus and Pregnancy on Local Goat

Jurnal Kedokteran Hewan, 2010
The aim of this research was to determine the percentage of estrus, performance of estrus, and percentage of pregnancy in local goat which synchronized with seminal vesicles extract.
Syafruddin S, Tongku Nizwan Siregar, Herrialfian H, T Armansyah, Arman Sayuti, Roslizawaty R   +5 more
doaj   +1 more source

Mapping Steroidogenic Perturbations Under Endocrine Disruptor Mixtures Across Demographic Subgroups: Structural and Metabolomic Insights

Advanced Science, EarlyView.
Population‐scale EDC–hormone association mapping among 4255 participants across demographic subgroups identifies phthalate metabolites as the most consistent signals associated with lower testosterone‐related markers in males. Integrative mechanistic validation prioritizes MCPP as a key phthalate metabolite linked to CYP17A1‐centered disruption of ...
Yanling Chen, Lei Huang, Yingtong Jiang, Guohong Zhao, Mengyuan Zhu, Xiulian Lu, Lang Lang, Akinpelumi Oluwatobiloba Esther, Longhao Fan, Yuqi Jiang, Chang Sun, Xiaoling Zhang, Kun Zhou, Xiaoming Ji, Minjian Chen   +14 more
wiley   +1 more source

Paternal Sperm Gnas‐ICR Epigenetic Programming Contributes to PPP‐Like Phenotypes in Female Offspring

Advanced Science, EarlyView.
A paternal glucocorticoid–sperm Gnas‐ICR axis is linked to ovarian endocrine programming in female offspring. Paternal preconception caffeine exposure elevates corticosterone, promotes sperm Gnas‐ICR hypermethylation, and is associated with ovarian Gnas upregulation, cAMP/PKA/CREB–StAR activation, enhanced estradiol synthesis, and PPP‐like phenotypes ...
Jing Huang, Lu Chen, Tiancheng Wu, Yating Li, Hui Wang   +4 more
wiley   +1 more source

EFEK PENYUNTIKAN PROSTAGLANDIN F2α (PGF2α) TERHADAP TIMBUL DAN LAMA BIRAHI SAPI BALI PADA PARITAS YANG BERBEDA

Ziraa'ah: Majalah Ilmiah Pertanian, 2019
The objective of this study was to evaluate of Effect of injection Prostaglandin F2α on the time required for onset of estrus and estrus durations in Bali cattle with differences of Paritas.
Abdul Malik
doaj   +1 more source

Kinerja Reproduksi Ternak Kerbau (Bubalus bubalis) pada Usaha Peternakan Rakyat di Kabupaten Klaten Provinsi Jawa Tengah

Jurnal Peternakan Indonesia, 2023
Penelitian ini memberikan informasi mengenai kinerja reproduksi kerbau betina di peternakan rakyat Kabupaten Klaten. Penelitian ini telah dilakukan pada April-September 2021 di Kabupaten Klaten.
Faris Tio Kurniawan, Yuli Yanti, Muhammad Cahyadi, Ari Kusuma Wati, Joko Riyanto, Ratih Dewanti, Wari Pawestri   +6 more
doaj   +1 more source