Results 51 to 60 of about 27,500 (174)

Real-World Experience of HER2-Positive Advanced Breast Cancer (ABC) Treatment and Evaluation of Blood Biomarkers in a Public Institution in Latin America (LATAM)

Breast Cancer: Basic and Clinical Research
Background: Advanced breast cancer (ABC) is an incurable disease, with a median overall survival (OS) of 3 years, even in high-income countries. Oncological treatment has improved survival rates, particularly for hormone receptor–positive and HER2 ...
Guillermo Valencia, Patricia Rioja, Olenka Peralta, Miguel Chirito, Raúl Mantilla, Carlos Castañeda, Zaida Morante, Hugo Fuentes, Tatiana Vidaurre, Mónica Calderón, Silvia Neciosup, Henry L Gómez   +11 more
doaj   +1 more source

Recommendations for genetic counseling for individuals at risk of autosomal dominant Alzheimer's disease in Latin America

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract Autosomal dominant Alzheimer's disease (ADAD) represents a small but impactful subset of Alzheimer's cases. Asymptomatic individuals at genetic risk face substantial personal and family implications when considering predictive testing for known familial variants.
Daniel A. Jiménez, Pablo M. Bagnati, Rosa Elena Flores‐Montes, María Laura Fernández, Angélica Zuno‐Reyes, David Aguillon, Carmen Alaez‐Verson, Luis E. Becerra‐Solano, María Isabel Behrens, Kelly Branda, Patricio Chrem, Nilton Custodio, Whitney Ducaine, Sofia Dumois‐Petersen, Luis Figuera, Marisol Londoño Castaño, Erika Mariana Longoria, Esmeralda Matute, Victor Sánchez, Andrea Slachevsky, Ana Luisa Sosa, Ezequiel Surace, Leonel Takada, Lauren Yaeger, Ellen Ziegemeier, Jorge J Llibre Guerra, for the Programa de asesoramiento genético en América Latina (PRAGA)   +26 more
wiley   +1 more source

Low‐intervention clinical trials in Spain: Do they progress?

British Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1438-1444, May 2026.
Abstract Aims Low‐Intervention Clinical Trials (LICTs) are generally pragmatic trials that investigate medicinal products already authorized for use. In 2014, simplified regulatory frameworks were introduced for LICTs with the aim of reducing regulatory burden and operational complexity, to foster non‐commercial clinical trials (NCCTs); the mandatory ...
Claudia Erika Delgado‐Espinoza, Mayro J. Cortés Pestana, Kristopher Amaro, Rosa M. Antonijoan, Caridad Pontes   +4 more
wiley   +1 more source

Diagnóstico Descriptivo de Procesos Con Base a la Teoría Relacional Objetal: Ejercicio de Lectura de un Caso Clínico

, 2022
Este artículo académico presenta un diagnóstico descriptivo de procesos teniendo como referencia la teoría relacional objetal desde la lógica de Horner.
Jiménez Beleño, Astrid Paola
core  

Real‐World Effectiveness and Safety of Upadacitinib in Crohn's Disease: Insights From the Eneida Registry

United European Gastroenterology Journal, Volume 14, Issue 4, May 2026.
ABSTRACT Background Upadacitinib (UPA) is the first oral Janus kinase (JAK) inhibitor approved for the treatment of Crohn's disease (CD). Real‐world data, particularly from large nationwide cohorts, remain limited. This study aimed to evaluate the real‐world effectiveness, safety, and treatment persistence of UPA in patients with CD.
M. Iborra, B. Botella, M. D. Martín‐Arranz, D. Ceballos, C. Martínez‐Pascual, A. Garrido, P. Varela, M. Moreta, E. Brunet‐Mas, Y. González‐Lama, E. Rodríguez‐González, M. Vicuña, J. P. Gisbert, I. Ordás, F. Argüelles‐Arias, J. Tosca‐Cuquerella, R. Vicente‐Lidón, M. Sierra‐Ausín, I. Rodríguez‐Lago, D. Martín‐Rodríguez, J. M. Paredes, B. Sicilia, I. García de la Filia, N. Jiménez, M. Barreiro‐de Acosta, E. Betoré, I. Ferrer‐Bradley, L. García‐Alles, J. M. Huguet, S. Castellet‐Farrús, M. J. García, A. Gutiérrez‐Casbas, Á. Ponferrada‐Díaz, L. Ramos, M. Calafat, I. Vera, C. Suárez‐Ferrer, E. Fernández‐Velado, S. Rodríguez‐Sánchez, A. Mínguez, A. Mancebo, J. Barrio, S. Lario, D. R. de La Cruz, Alejandro Hernández‐Camba, C. Rodríguez‐Gutiérrez, M. Chaparro, E. Ricart, L. Almenara‐Michelena, A. Balaguer, E. Domènech, P. Nos   +51 more
wiley   +1 more source

Estudios clínicos con inhibidores de la PCSK9

Revista Colombiana de Cardiología, 2017
Los inhibidores de la enzima proproteína convertasa subtilisina kexina tipo 9 (PCSK9) constituyen una herramienta terapéutica novedosa para el selecto grupo de pacientes de muy alto riesgo en quienes no se han alcanzado las metas de colesterol LDL.
Rafael Campo
doaj   +1 more source

First‐trimester prediction and prevention of preterm pre‐eclampsia in women with chronic hypertension

Ultrasound in Obstetrics &Gynecology, Volume 67, Issue 5, Page 613-622, May 2026.
ABSTRACT Objectives To evaluate the effect of aspirin on gestational age at delivery due to preterm pre‐eclampsia (PE) in women with chronic hypertension (CH), to assess the predictive performance of the Fetal Medicine Foundation (FMF) first‐trimester competing‐risks model for preterm PE in this high‐risk group and to evaluate how parity, previous PE ...
D. L. Rolnik, S. Gil‐Pugliese, A. Syngelaki, E. Bujold, D. Wright, L. C. Poon, K. H. Nicolaides, ASPRE and SPREE Collaborators, C. de Paco Matallana, D. Janga, E. Greco, F. S. Molina, G. Papaioannou, H. Meiri, J. C. Jani, K. Maclagan, K. Tenenbaum‐Gavish, M. Singh, M. Y. Tan, N. O'Gorman, N. Persico, R. Akolekar, S. Cicero, W. Plasencia   +23 more
wiley   +1 more source

Tendencia de publicación de ensayos clínicos con resultados negativos financiados por industrias farmacéuticas durante el periodo 2007-2012

Revista Ciencias de la Salud, 2015
Objetivo: Evaluar los resultados de ensayos clínicos financiados por la industria farmacéutica durante el periodo 2007-2012 en una revista médica general.
Evert A. Jiménez-Cotes, Laura Mejía-Cardona, Jorge H. Donado-Gómez   +2 more
doaj   +1 more source

Longitudinal maternal hemodynamics in high‐risk pregnancies with different subtypes of pre‐eclampsia

Ultrasound in Obstetrics &Gynecology, Volume 67, Issue 5, Page 623-634, May 2026.
ABSTRACT Objective To evaluate maternal cardiac adaptation during pregnancy by comparing longitudinal hemodynamic profiles between women identified as high risk for preterm pre‐eclampsia (PE) who subsequently developed preterm PE, term PE or remained unaffected, as well as low‐risk women.
J. Lin, X. Wang, Y. Chen, L. Nguyen‐Hoang, A. S. T. Tai, I. S. Wong, X. Y. Chen, M. H. Ng, H. H. Y. Leung, A. P. W. Lee, L. C. Poon   +10 more
wiley   +1 more source

Inteligencia de estudios clínicos

, 2019
Los estudios clínicos o ensayos clínicos son necesarios para evaluar la eficacia y seguridad de un tratamiento. Sin embargo, a pesar de la existencia de portales de registros clínicos, estos estudios tienen dificultades en el reclutamiento de voluntarios,
Herranz Cayuela, Héctor
core