Results 11 to 20 of about 26 (26)
Abstract Objective Asthma is a chronic disease that may affect physical fitness, although its primary effects on exercise capacity, muscle strength, functionality and lifestyle, in children and adolescents, are still poorly understood. This study aimed to evaluate the differences in cardiorespiratory fitness, muscle strength, lifestyle, lung function ...
Verónica Sanz‐Santiago +10 more
wiley +1 more source
Pseudohypoxic pheochromocytomas and paragangliomas dominate in children
Abstract Objective Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors that are associated with cancer predisposition syndromes in up to 80% of affected children. PPGLs can be divided into molecularly defined groups with comparable pathogenesis and biology: (1) pseudohypoxic, (2) kinase signaling, and (3) Wnt‐altered. Methods We
Antje Redlich +5 more
wiley +1 more source
Recent advancements in surface plasmon resonance protocols and simulations have enhanced the measurement and prediction of diffusion coefficients (D) for chemical species in microfluidic channels. These developments enable precise determination of D values for molecules ranging from a few angstroms to nanometric aggregates, facilitating detailed ...
Giuseppe Stefano Basile +4 more
wiley +1 more source
Amyloid‐β (Aβ) oligomers affect VDAC1 electrophysiology and the physiological metabolic cross‐talk between cytosol and mitochondria. The use of a small, synthetic VDAC1‐antagonist peptide, derived from hexokinase, restores mitochondrial functionality, and respiration in cellular models of Alzheimer's disease. ABSTRACT Mitochondrial dysfunction has been
Fabrizio Cavallaro +10 more
wiley +1 more source
Abstract Objective This study aimed to identify prescribing behaviors in women of childbearing potential (WOCP) with epilepsy already taking valproate (VPA), and to investigate the relationship between VPA maintenance, substitution, reduction, or withdrawal as part of polytherapy, and seizure worsening or relapse.
Roberta Esposto +16 more
wiley +1 more source
The manuscript introduces a new methodology using Surface Plasmon Resonance (SPR) coupled with stochastic simulations. It reveals albumin′s conformational changes by tracking its diffusion coefficient (D). This approach monitors albumin′s structure in real time under various conditions, including enzymatic cleavage. The findings offer new insights into
Damiano Calcagno +6 more
wiley +1 more source
Research and Practice in Thrombosis and Haemostasis, Volume 5, Issue S2, October 2021.
wiley +1 more source
This study introduces a new model to describe and fit the behavior of diffusion coefficients (D) as a function of molecular structure and thermodynamic parameters in binary solutions of linear chain organic molecules. The model is validated using surface plasmon resonance (SPR) experiments and molecular dynamics (MD) simulations for a series of n ...
Giuseppe Stefano Basile +7 more
wiley +1 more source

