Results 31 to 40 of about 3,129,690 (306)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

The pyruvate generator is a common phenomenon in mitochondria from different rat and mouse brain regions

open access: yesFEBS Letters, EarlyView.
The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber   +7 more
wiley   +1 more source

Argumentation – Evidentiary Procedure in Criminal Proceedings

open access: yesSEEU Review, 2018
The continuous increase in criminal activities in all countries, namely the offences which undermine the interests of contemporary societies, call for the need to fight them in a more successful manner.
Mehmeti Valon
doaj   +1 more source

O livro paradidático no ensino de Física: uma análise fabular, científica e metafórica da obra Alice no País do Quantum: A Física Quântica ao alcance de todos

open access: yesCaderno Brasileiro de Ensino de Física, 2016
Neste artigo apresentamos uma análise fabular, científica e metafórica da obra Alice no País do Quantum: A Física Quântica ao alcance de todos. O objetivo é apresentar, através da análise, subsídios que contemplem ao professor de escolas de Ensino Médio,
Aguinaldo Robinson de Souza   +1 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

open access: yesFEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Enhancing predictive modeling across industries with automated machine learning: applications in insurance and agriculture

open access: yesDiscover Sustainability
This study explores the efficacy of Automated Machine Learning (AutoML) tools in enhancing linear regression models across industries, focusing on insurance and agriculture.
K. P. Swain   +2 more
doaj   +1 more source

Multistakeholder Policy Formulation and Action Planning for Urban Agriculture in Lima, Peru

open access: yesJournal of Agriculture, Food Systems, and Community Development, 2016
Multistakeholder processes are increasingly consid­ered to be an important element of policy design, action planning, and implementation. By involving a broad base of stakeholders, municipal authorities are more likely to develop policies and programs ...
Marielle C. E. Dubbeling   +2 more
doaj   +1 more source

Gluten free approach of biscuits preparation

open access: yesJournal of Agriculture and Food Research, 2023
Replacement of gluten is a challenging issue in preparation of the bakery products. The present work aimed to develop gluten-free biscuits by using gluten-free flours like rice, sorghum, and corn in different ratios (0, 25, 33.33, 50, and 100%).
Deepika Kohli   +3 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

open access: yesFEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik   +6 more
wiley   +1 more source

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