Results 41 to 50 of about 13,081,117 (322)

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Assessment of Feasibility of Sintered Fly Ash Lightweight Aggregate as an Effective Self-Curing Additive for Sustainable Concreting Practice [PDF]

E3S Web of Conferences
Effective curing is an essential requirement for a desired long-term performance of concrete. For 1 cubic metre of hardened concrete, 3 cubic metre of water is required; most of which is consumed for curing, thereby leading to an unsustainable practice ...
Patil Dada, Nadaf Firoz, Parkar Fauwaz
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A secure IoT-edge architecture with data-driven AI techniques for early detection of cyber threats in healthcare

Discover Internet of Things
The latest developments in the Internet of Medical Things (IoMT) have transformed healthcare, allowing for the easy transmission of sensitive data across networked medical equipment.
Mamta Kumari, Mahendra Gaikwad, Salim A. Chavan   +2 more
doaj   +1 more source

Safety and efficacy of ETC-1002 in hypercholesterolaemic patients: a meta-analysis of randomised controlled trials.

Kardiologia polska, 2019
BACKGROUND Due to the myopathic adverse events of statins, safer alternatives are being studied. Bempedoic acid (ETC-1002) is a novel low-density lipoprotein cholesterol (LDL-C)-lowering agent, currently under trial in hypercholesterolaemic patients ...
Xiaolin Wang, Shilan Luo, Xiuni Gan, Chengyu He, Rongzhong Huang   +4 more
semanticscholar   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Gluten free approach of biscuits preparation

Journal of Agriculture and Food Research, 2023
Replacement of gluten is a challenging issue in preparation of the bakery products. The present work aimed to develop gluten-free biscuits by using gluten-free flours like rice, sorghum, and corn in different ratios (0, 25, 33.33, 50, and 100%).
Deepika Kohli, Akshita Jain, Omprakash Singh, Sanjay Kumar   +3 more
doaj   +1 more source

Study of an Alternate Mechanism for the Origin of Fermion Generations

, 2010
In usual extended technicolor (ETC) theories based on the group ${\rm{SU}(N_{ETC}})_{ETC}$, the quarks of charge 2/3 and -1/3 and the charged leptons of all generations arise from ETC fermion multiplets transforming according to the fundamental ...
C.T. Hill, D. Hong, D.D. Dietrich, E. Farhi, F. Sannino, F. Sannino, J.C. Pati, N. Chen, N.D. Christensen, N.D. Christensen, R. Foadi, R.N. Mohapatra, Robert Shrock, S.B. Gudnason, T. Appelquist, T. Appelquist, T. Appelquist, T. Ryttov, Thomas A. Ryttov   +18 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Enhancing predictive modeling across industries with automated machine learning: applications in insurance and agriculture

Discover Sustainability
This study explores the efficacy of Automated Machine Learning (AutoML) tools in enhancing linear regression models across industries, focusing on insurance and agriculture.
K. P. Swain, S. K. Mohapatra, Santosh Kumar Sahoo   +2 more
doaj   +1 more source