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The neurotoxicity of ethanol

Acta Neurologica Scandinavica, 1983
Alterations in nervous system functioning following acute and chronic ethanol exposure have been studied in a great number of experimental investigations. Results from many of these investigations can be difficult to interpret, particularly since a variety of techniques and exposure models are employed.
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Ethanol and polyneuropathy

Acta Neurologica Scandinavica, 2009
Two groups of alcoholics (30 patients each)--identified by the MALT score--were examined. Clinical and laboratory investigations showed no connection between thiamine, riboflavin, or Vitamin B6 deficiency and development of the polyneuropathy. Neither the polyneuropathy nor the diminished sensory conduction velocity were related to malnutrition.
R. Eggers   +4 more
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Effects of Ethanol and Ethanol Withdrawal on Nociception in Rats

Alcoholism: Clinical and Experimental Research, 1999
The effect of acute and chronic administration of ethanol and ethanol withdrawal on a radiant heat tail‐flick assay of nociception was examined in rats. Acute administration of ethanol (2.0 g/kg, ip) produced peak antinociception (68% of maximum) by 30 min, and effects were gone by 120 min.
Harbans Lal, Michael B. Gatch
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Ethanol tolerance and ethanol-drug interactions in the rat

Toxicology and Applied Pharmacology, 1972
Abstract Tolerance to the hypnotic effect of ethanol was induced with adifferent time course in adult male and female Holtzman rats by repeated ip administration of ethanol (2.5 g/kg/day). Female rats exhibited tolerance to ethanol after 10 days of treatment and males at 15 days. The extinction of ethanol tolerance was similar in both sexes. Although
Garry K. Hatfield   +2 more
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Ethanol and the Pancreas

Medical Clinics of North America, 1984
The acute and chronic effects of ethanol on pancreatic structure and function are discussed. Acute necrotizing, acute edematous, acute relapsing, chronic relapsing, and painless pancreatitis have an established association with ethanol abuse. The management of these disorders is outlined.
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Ontogeny of ethanol elimination and ethanol-induced hypothermia

Alcohol, 2000
Ontogeny of ethanol elimination rates and ethanol-induced hypothermia were examined as possible mechanisms contributing to the marked reduction in ethanol sensitivity early in life (Little et al., 1996; Silveri & Spear, 1998) and the notable gender difference in ethanol sleep-time seen in adult animals (Silveri & Spear, 1998).
Marisa M. Silveri, Linda P. Spear
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Ethanol-induced apoptotic neurodegeneration and fetal alcohol syndrome.

Science, 2000
The deleterious effects of ethanol on the developing human brain are poorly understood. Here it is reported that ethanol, acting by a dual mechanism [blockade of N-methyl-D-aspartate (NMDA) glutamate receptors and excessive activation of GABA(A ...
C. Ikonomidou   +11 more
semanticscholar   +1 more source

Ethanol Clusters in Gasoline-Ethanol Blends

Industrial & Engineering Chemistry Research, 2016
Formation of ethanol clusters in gasoline-ethanol fuel blends was studied by pulsed-field-gradient NMR measurement of diffusion of ethanol molecules. The results, consistent with a simple model of clusterization, show that ethanol molecules form hydrogen-bonded clusters with concentration- and temperature-dependent average size.
Anatoly K. Khitrin, Alexander Turanov
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Metabolism of ethanol

Journal of the American Dietetic Association, 1980
The first step in ethanol metabolism is carried out by two enzyme systems: Alcohol dehydrogenase and cytochrome P-450. The cytochrome P-450 system also detoxifies a wide variety of foreign compounds. On the basis of recent evidence, metabolic reasons are suggested for four well-known consequences of alcoholism: (a) The development of fatty liver; (b ...
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Acute Ethanol Poisoning and the Ethanol Withdrawal Syndrome

Medical Toxicology, 1988
Ethanol, a highly lipid-soluble compound, appears to exert its effects through interactions with the cell membrane. Cell membrane alterations indirectly affect the functioning of membrane-associated proteins, which function as channels, carriers, enzymes and receptors.
George H. A. Bone   +2 more
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