Results 71 to 80 of about 56,542 (268)

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source

Loss of Ethanolamine Utilization in Enterococcus faecalis Increases Gastrointestinal Tract Colonization

mBio, 2018
Enterococcus faecalis is paradoxically a dangerous nosocomial pathogen and a normal constituent of the human gut microbiome, an environment rich in ethanolamine. E. faecalis carries the eut (ethanolamine utilization) genes, which enable the catabolism of
Karan Gautam Kaval, Kavindra V. Singh, Melissa R. Cruz, Sruti DebRoy, Wade C. Winkler, Barbara E. Murray, Danielle A. Garsin   +6 more
doaj   +1 more source

Identification of the Target Binding Site of Ethanolamine-Binding Aptamers and Its Exploitation for Ethanolamine Detection

, 2016
Aptamers are promising recognition elements for sensitive and specific detection of small molecules. We have previously selected ssDNA aptamers for ethanolamine, one of the smallest aptamer targets so far.
Alexandra Heilkenbrinker (1694176), Frank Stahl (320272), André Jochums (1694179), Thomas Scheper (1409467), Regina Stoltenburg (776895), Stefan Zimmermann (1694173), Johanna-Gabriela Walter (1409452), Christine Reinemann (1694182), Beate Strehlitz (776896)   +8 more
core   +1 more source

Targeting DNGR‐1 with Fangchinoline Elevates Dendritic Cell Antigen Cross‐Presentation‐Mediated Antitumor Immunity in Melanoma

Advanced Science, EarlyView.
Fangchinoline is identified as a small‐molecule DNGR‐1 modulator that enhances dendritic‐cell cross‐presentation of tumor antigens. By engaging DNGR‐1 and activating Syk–Nox2 signaling, it promotes phagosomal ROS, antigen escape, MHC‐I presentation, and CD8+ T‐cell priming, thereby strengthening antitumor immunity and sensitizing tumors to PD‐1 ...
Yuan Liao, Zhenyang Ren, Jing Zhou, He Luo, Yuling Li, Dan Chen, Yuxiao Jiang, Canzhe Li, Mengyi Zheng, Anqi Li, Yao Wang, Yang Zhang, Dingye Wang, Yanjun Jiang, Jiangyong Gu, Biaoyan Du, Yafei Shi, Fang Liu, Jianyong Xiao, Kun Wang   +19 more
wiley   +1 more source

The alk-1-enyl group content of mammalian myelin phosphoglycerides by quantitative two-dimensional thin-layer chromatography

Journal of Lipid Research, 1968
Myelin phospholipids have been examined by a separation-reaction-separation procedure for two-dimensional thin-layer chromatography on silica gel. After separation in one dimension, alk-1-enyl groups are cleaved by exposure of the plates to HCl fumes ...
Lloyd A. Horrocks
doaj   +1 more source

Ethanolamine Transport in Human Placental Brush-Border Membrane Vesicles

, 2020
Pathways for transport of ethanolamine by human placental epithelia were investigated by measurement of [ 3 H]ethanolamine uptake in brush-border membrane vesicles isolated by divalent cation precipitation. The presence of a conductive uptake pathway for
Steven M Grassl
core  

Purification and Biochemical Characterization of Ethanolamine Kinase from Spinach [PDF]

, 1994
Ethanolamine kinase (EC 2.7.1.82) catalyses the reaction of ethanolamine and Mg^2+-ATP to produce phosphoethanolamine and Mg^2+ -ADP. For spinach (Spinacia oleracea) the activity of ethanolamine kinase is increased in leaf extracts of salinized plants. A
Mercer, Shelly
core  

Facile Fabrication of Low‐Impedance, Highly Conformal Epidermal Electrodes Based on Laser‐Induced Graphene–Silver Nanocomposites

Advanced Science, EarlyView.
A facile laser‐induced graphene–silver nanocomposite strategy enables ultrathin epidermal electrodes with low impedance, high conductivity, and excellent mechanical robustness. The porous LIG–Ag conductive network mechanically interlocked with SEBS provides stable, motion‐resistant biopotential monitoring, enabling high‐fidelity ECG, EMG, and EEG ...
Jiuqiang Li, Senhao Zhang, Kai Guo, Donghai Qiu, Juzhong Zhang, Hongbo Yang, Huanyu Cheng   +6 more
wiley   +1 more source

Inactivation of Anandamide Signaling: A Continuing Debate

Pharmaceuticals, 2010
Since the first endocannabinoid anandamide was identified in 1992, extensive research has been conducted to characterize the elements of the tightly controlled endocannabinoid signaling system.
Wael E. Houssen, Hesham Khairy
doaj   +1 more source

Enhanced Performance of Optoelectronic Devices Using Metal Chalcogenide Complex Ligands‐Capped InAs/ZnSe Quantum Dots as Electron Transport Layers

Advanced Energy Materials, EarlyView.
Thin‐shell InAs/ZnSe quantum dots functionalized with metal chalcogenide ligands were employed as electron transport layers in organic optoelectronic devices, yielding optimized conduction band alignment and film morphology. Consequently, the devices achieved enhanced charge transport, a detectivity of ∼1013 Jones, and a power conversion efficiency of ...
Yonghoon Choi, Seyeong Song, Dain Choi, Jinho Shin, Yeonjeong Lee, Jaehyeong Kim, Jeongmin Son, Jin Young Kim, Jongnam Park   +8 more
wiley   +1 more source