Results 221 to 230 of about 491,730 (254)

Trafficking Deficiency of TMEM175 Variants in Parkinson's Disease Pathogenesis and the Prospects of Precision Medicine

open access: yesAdvanced Science, EarlyView.
This study identifies that the PD‐associated TMEM175‐L156P variant disrupts lysosomal ion channel trafficking by causing aberrant endoplasmic reticulum retention. A “chaperone–agonist” bifunctional small molecule restores TMEM175‐L156P lysosomal localization and channel function, thereby alleviating PD‐relevant cellular phenotypes and highlighting a ...
Ting Luo   +17 more
wiley   +1 more source

Human Foetal Neuroblasts Exhibit BK Channel‐Dependent Membrane Voltage Oscillations upon Depolarization

open access: yesAdvanced Science, EarlyView.
Primary cultures of neuroblasts isolated from the nucleus basalis of Meynert of 12‐weeks‐old human foetuses were prepared. Whole‐cell patch‐clamp recordings were performed by injecting a depolarizing stimulus current (+500 pA; 500 ms), and the membrane voltage recorded; this stimulus current evoked periodic‐like oscillations in membrane voltage ...
Elisabetta Coppi   +9 more
wiley   +1 more source

Non-Superacid-Catalyzed Preparation of Anion Exchange Membranes for High-Performance Water Electrolyzers. [PDF]

open access: yesAngew Chem Int Ed Engl
Shi J   +9 more
europepmc   +1 more source

Millisecond Spin Relaxation Times of Distinct Electron and Hole Subensembles in MAxFA1−xPbI3 Perovskite Crystals

open access: yesAdvanced Science, EarlyView.
Mixed‐cation MAx${\rm MA}_x$ FA1−x${\rm FA}_{1-x}$ PbI3${\rm PbI}_3$ perovskite crystals reveal multiple discrete electron and hole spin subensembles associated with distinct localization environments. Optically detected magnetic resonance combined with resonant spin inertia uncovers carriers spin relaxation times reaching 2 ms and identifies nuclear ...
Rongrong Hu   +6 more
wiley   +1 more source

Exposure dose-dependent multi-tone photolithography via photoacid-induced crosslinking and degradation of poly(2,3-dihydrofuran). [PDF]

open access: yesNat Commun
Huang JD   +11 more
europepmc   +1 more source

Anionic solvation reconstruction stabilizes interfacial chemistry for high-temperature and high-voltage Li metal batteries. [PDF]

open access: yesNat Commun
Shi Z   +10 more
europepmc   +1 more source

Na- and K-Iminophosphorane-Phosphine Oxide Complexes as Catalysts for ROP of rac-Lactide. [PDF]

open access: yesChempluschem
Caballero-Jiménez DJ   +3 more
europepmc   +1 more source

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