Results 21 to 30 of about 437,981 (287)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

open access: yesFEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani   +6 more
wiley   +1 more source

CULTURE AND INSTITUTIONS INTO EVOLUTIONAL ECONOMICS: CONCEPIUAL APPROACH TO THE ANALYSIS

open access: yesВестник СибАДИ, 2017
The methodology of the study of the relationship between culture and institutions in economic processes is proposed. Cultural-value system as a special component of the economic reality, contributing to the formation of the institutional shell is ...
V. V. Biryukov, E. V. Romanenko
doaj   +1 more source

ATMAN, IDENTITY, AND EMANATION: ARGUMENTS FOR A HINDU ENVIRONMENTAL ETHIC [PDF]

open access: yes, 2011
Many contemporary authors argue that since certain Hindu texts and traditions claim that all living beings are fundamentally the same as Brahman (God), these texts and traditions provide the basis for an environmental ethic.
Framarin, Christopher G.
core   +1 more source

A 3D Astrocyte Microenvironment Model Enables Rapid Ca2+‐Resolved Analysis and Therapeutic Modulation of Oxidative Neuroinflammation

open access: yesAdvanced Healthcare Materials, EarlyView.
This work presents ARC‐3D, a soft 3D model that recreates how brain support cells, called astrocytes, react to oxidative stress. The system visualizes rapid calcium changes and inflammatory signals, and shows how the drug KDS12025 can protect cells from damage. ARC‐3D offers a simple, reliable way to study early drivers of brain inflammation.
Ju‐Kang Kim   +6 more
wiley   +1 more source

Membrane Semi‐Permeability and Ion Selectivity in Chemiosmosis: Open Systems Volume Dependence of Electrolyte Chemistry

open access: yesAdvanced Materials Interfaces, EarlyView.
Very small cellular compartments can break electroneutrality and harness proton gradients without active transport structures, whereas larger volumes cannot, underscoring why life's critical energy processes are confined in microscopic spaces. ABSTRACT The effect of pH changes in external ionic solutions on liposomes entrapping non‐permeable weak acid ...
Josep M. Ribó   +4 more
wiley   +1 more source

A systematic analysis of the Polish Code of Medical Ethics

open access: yesJournal of Education, Health and Sport, 2019
The purpose of this article is to provide a summary of the history which led to the creation of the current structure of the self-regulatory professional body of physicians and dentists, the nature of the professional activities and practice of ...
Anna Augustynowicz   +4 more
doaj   +1 more source

F‐Box and Leucine‐Rich Repeat Protein 4 (FBXL4) Maintains Sarcomere Integrity and Cardiac Function by Enhancing K48‐Linked Ubiquitinated Degradation of Profilin‐1 (PFN1)

open access: yesAdvanced Science, EarlyView.
Schematic diagram depicting the proposed signaling mechanisms underlying the effects of FBXL4 in the setting of cardiac hypertrophy. Under hypertrophic stimulation, cardiomyocytes‐specific overexpression FBXL4 maintains sarcomere integrity and cardiac function by enhancing K48‐linked ubiquitinated degradation of PFN1 at the K70 site.
Xingda Li   +11 more
wiley   +1 more source

Note introductive au texte de Richard Stanley Peters, « L’éducation comme initiation »

open access: yesPenser l'Éducation, 2023
In ordinary words, education is regularly viewed through the prism of its extrinsic consequences and purposes (integration into society, vocational training, etc.). For the English philosopher Richard S.
Pierre Gégout
doaj   +1 more source

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