Results 31 to 40 of about 437,670 (287)

Note introductive au texte de Richard Stanley Peters, « L’éducation comme initiation »

Penser l'Éducation, 2023
In ordinary words, education is regularly viewed through the prism of its extrinsic consequences and purposes (integration into society, vocational training, etc.). For the English philosopher Richard S.
Pierre Gégout
doaj   +1 more source

Ethical ethics committees? [PDF]

Journal of Medical Ethics, 2000
sir At a recent health authority meeting Professor Stacey, the NHSE Head of Research Ethics, was quoted as stating that for multicentre trials rapid responses were required …
openaire   +2 more sources

A Novel Function of Nonadecanoic Acid in Regulating Glucose Homeostasis

Advanced Science, EarlyView.
This study identifies the odd‐chain fatty acid C19:0 as an endogenous ligand of GPR120 that promotes glucose homeostasis via Gαq signaling. In obesity, elevated palmitic acid suppresses endogenous C19:0 production through a miRNA–PPARα–HACL1 pathway, offering a promising direction for understanding the role of OCFAs in human health.
Yanting Hou, Yinghua Ma, Qin Liu, Dingling Ma, Yuxin Tong, Lili Xu, Xiaolong Chu, Jingzhou Wang, Maodi Liang, Mengyuan Zhao, Huizi Zhang, Yurui Su, Jianxin Xie, Cuizhe Wang, Jun Zhang   +14 more
wiley   +1 more source

Studying the principles of governance in Nahjolbalaghe and Siaasatnaameh (By relying on governors' ethic and responsibilities) [PDF]

نثرپژوهی ادب فارسی, 2018
What is remarkable in this research is, studying the governance and its style regarding the remarks represented by Imam Ali in Nahjolbalagheh and Eunuch Nezamolmolk Tousi in Siaasatnaameh by  relying on governors' ethic and responsibilities.
gholamreza heidary
doaj   +1 more source

BGN/MDK Axis in the Melanoma Tumor Microenvironment Strengthens Tumor Malignancy by Modulating Cancer Cells and Cancer‐Associated Fibroblasts Crosstalk

Advanced Science, EarlyView.
This study reveals that m6A regulators cooperatively upregulate BGN in melanoma, promoting malignancy. Within the tumor microenvironment, CAFs show highest BGN expression. The BGN/MDK axis mediates cancer‐stroma crosstalk, driving normal fibroblast (NF) activation and enhancing the pro‐tumor effect of CAFs, highlighting a promising therapeutic target ...
Hao‐ze Shi, Ming‐yang Wu, Jin‐quan Liu, Cuicui Tian, Li Ma, Xue‐mei Zhou, Ze‐Hao Sun, Zhi‐yong Xu, Run‐dong Zhang, Shan‐yuan Ye, Li‐ming Huang, Yan Wang, Jing‐shu Xiong, Wen‐bo Bu, Xian‐feng Cheng, Jian‐fang Sun, Hao Chen   +16 more
wiley   +1 more source

Integrating Spatial Proteogenomics in Cancer Research

Advanced Science, EarlyView.
Xx xx. ABSTRACT Background: Spatial proteogenomics marks a paradigm shift in oncology by integrating molecular analysis with spatial information from both spatial proteomics and other data modalities (e.g., spatial transcriptomics), thereby unveiling tumor heterogeneity and dynamic changes in the microenvironment.
Yida Wang, Yang Wu, Feng Zhang, Parthiban Periasamy, Haiyue You, Denise Goh, Rachel Elizabeth Ann Fincham, Xin Ning, Danping Wu, Lu Liu, Ying Jiang, Zhiwen Qian, Joe Yeong, Yan Zhang   +13 more
wiley   +1 more source

Single‐Cell Dissection of Tumor‐Infiltrating Lymphocytes Reveals Cellular Architecture Predictive of Therapeutic Efficacy in Acral Melanoma

Advanced Science, EarlyView.
Autologous tumor‐infiltrating lymphocyte (TIL) therapy shows promising efficacy in acral melanoma, yet determinants of durable response remain unclear. By integrating single‐cell transcriptomics and TCR sequencing, this study reveals that TIL products enriched for T follicular helper and intermediate exhausted T cells establish persistent clonal ...
Chao Zhang, Wanyi Xiao, Hongru Shen, Fenge Li, Ting Li, Weihong Zhang, Haotian Liu, Ziwei Gao, Hongyu Wang, Xiubao Ren, Kexin Chen, Xiangchun Li, Jilong Yang   +12 more
wiley   +1 more source

Síndrome metabólica em ambulatório cardiológico Síndrome metabólico en ambulatorio cardiológico Metabolic syndrome in outpatient cardiology clinics

Arquivos Brasileiros de Cardiologia, 2010
FUNDAMENTO: No Brasil, a prevalência de síndrome metabólica (SM) é pouco conhecida em várias regiões. OBJETIVO: Analisar a prevalência da SM, seus componentes e a concordância entre dois critérios diagnósticos numa população com idade > 13 anos. MÉTODOS:
José Bonifácio Barbosa, Antonio Augusto Moura da Silva, Fabrício de Flores Barbosa, Francisco das Chagas Monteiro Júnior, José Albuquerque de Figueiredo Neto, Vinicius José da Silva Nina, Waston Gonçalves Ribeiro, Eduardo Durans Figuerêdo, José Xavier de Melo Filho, Maria Bethânia da Costa Chein   +9 more
doaj   +1 more source

The King’s New Clothes in the Eyes of the Beholder: Developing a Measurement Scale for Attitude Towards Corruption. [PDF]

, 2009
This study investigates the validity and reliability of a developing scale on attitude towards corruption. It correlates this scale with existing and related behavioural measures, both ethical (money ethic, work ethic and corruption perception) and non ...
Bello, M., Gbadamosi, Gbolahan
core   +1 more source

First Generation Proteolysis Targeting Chimeras (PROTACs) for the Treatment of Progeria

Advanced Science, EarlyView.
We report the first PROTACs designed to degrade progerin, introducing a novel therapeutic approach for progeria. The best compound, UCM‐18142, significantly reduces progerin levels and improves key disease phenotypes in patient‐derived cells and in the LmnaG609G/G609G mouse model, paving the way for new treatment strategies targeting the root cause of ...
Jon Macicior‐Michelena, Marcelino Telechea, Daniel Fernández, Alba García‐Martín, Ángeles Canales, Silvia Ortega‐Gutiérrez   +5 more
wiley   +1 more source