Results 101 to 110 of about 674,664 (261)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

A conceptual ethical framework to preserve natural human presence in the use of AI systems in education

Frontiers in Artificial Intelligence
In recent years, there has been a remarkable increase of interest in the ethical use of AI systems in education. On one hand, the potential for such systems is undeniable.
Werner Alexander Isop
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

No harm, no foul: The outcome bias in ethical judgments [PDF]

We present six studies demonstrating that outcome information biases ethical judgments of others' ethically-questionable behaviors. In particular, we show that the same behaviors produce more ethical condemnation when they happen to produce bad rather ...
Don A. Moore, Max H. Bazerman, Francesca Gino   +2 more
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Becoming: Shaping Leader Identity Through Ethical Behavior. [PDF]

HCA Healthc J Med, 2021
Sanders YT.
europepmc   +1 more source

Software piracy at work place: influence of organizational culture in the presence of various ethical orientations

Technology in terms of ‘information technology’ is a revolutionary discovery from time to time. On the similar note, one of the famous issues of IT is the Software Piracy, which has been the talk of the organizations every now and then. Software Piracy i.
Osman, Ms. Amber, Subhani, Muhammad Imtiaz, Hasan, Syed Akif   +2 more
core  

Unfolding a Product’s Ethical Bundle

, 2010
The aim of the current paper is to examine the relative importance and trade-offs of the attributes that compose an ethical product as perceived by consumers.
Vassilikopoulou, Aikaterini, Theofilou, Anastasios   +1 more
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Ethical Behavior Analysis: Evidence-Based Practice as a Framework for Ethical Decision Making. [PDF]

Behav Anal Pract, 2022
Contreras BP, Hoffmann AN, Slocum TA.
europepmc   +1 more source