Results 31 to 40 of about 88,220 (235)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

A Spiritual Analysis of the ASN East Java Province Workplace, the Ethical Approach, and the Organization's Dedication to Addressing Deviant Behavior

Indonesian Interdisciplinary Journal of Sharia Economics
This research aims at examining and analyzing: (1) the effect of ethical climate on deviant behavior; (2) the effect of workplace spirituality on deviant behavior; (3) the effect of organizational commitment on deviant behavior; (4) the effect of ...
Amiruddin Amiruddin, Dhenny Asmarazisa, Catur Fatchu Ukhriyawati   +2 more
doaj   +1 more source

The causal relationship between moral leadership and moral climate on the fatigue of nurses with the mediating role of perceived stress [PDF]

Journal of Research in Psychopathology
The present study aimed to test the structural model of the effect of ethical leadership and ethical climate on nurses' fatigue, with an emphasis on the mediating role of perceived stress.
mohammad Amin Musaie, Mohammad Abbasi
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Exploring the mechanisms of influence of ethical leadership on employment relations

IIMB Management Review, 2019
Alarmed by the frequent recurrence of industrial unrest, scholars in the field of employment relations have started to revisit the factors influencing employees’ perception of industrial relations climate.
Jatinder Kumar Jha, Manjari Singh
doaj   +1 more source

The Effect of Paternalistic Leadership on Organisational Ethical Climate: The Role of Organisational Justice As A Moderating Variable

Indonesian Journal of Business and Entrepreneurship, 2020
This study examines the effect of paternalistic leadership on organisational ethical climate and the role of organisational justice as a moderating variable.
Anindya Diah Mentari, Claudius Budi Santoso   +1 more
doaj   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

Ethical Climate and Creativity: The Moderating Role of Work Autonomy and the Mediator Role of Intrinsic Motivation

Management Letters/Cuadernos de Gestión, 2023
The current business context needs trust as a continuous mechanism of relationship with employees, because along with responsibility and moral standards, they configure a climate where the main perception is that the way of operating adjusts to ethical ...
Carlos Santiago-Torner
doaj   +1 more source

Network Localization of Fatigue in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Fatigue is among the most common symptoms and one of the main factors determining the quality of life in multiple sclerosis (MS). However, the neurobiological mechanisms underlying fatigue are not fully understood. Here we studied lesion locations and their connections in individuals with MS, aiming to identify brain networks ...
Olli Likitalo, Jaakko Kungshamn, Albert Bellmunt‐Gil, Silvia Tommasin, Abhineet Ojha, Matias Viitala, Juho Aaltonen, Jyrki Lötjönen, Juha Koikkalainen, Pauli Ylikotila, Patrizia Pantano, Merja Soilu‐Hänninen, Juho Joutsa   +12 more
wiley   +1 more source

Ethical decision-making climate, moral distress, and intention to leave among ICU professionals in a tertiary academic hospital center

BMC Medical Ethics, 2022
Background Commentators believe that the ethical decision-making climate is instrumental in enhancing interprofessional collaboration in intensive care units (ICUs).
Henry Silverman, Tracey Wilson, Samuel Tisherman, Raya Kheirbek, Trishna Mukherjee, Ali Tabatabai, Karen McQuillan, Rachel Hausladen, Melissa Davis-Gilbert, Eunsung Cho, Kerri Bouchard, Samantha Dove, Julie Landon, Michele Zimmer   +13 more
doaj   +1 more source