Results 201 to 210 of about 38,188 (263)

Clinical trial barriers in neurostimulation for pediatric drug‐resistant epilepsy

Epileptic Disorders, EarlyView.
Abstract Objective The NeuroPace responsive neurostimulation (RNS) System effectively treats focal drug‐resistant epilepsy (DRE) in adults but lacks pediatric regulatory approval. Despite effective off‐label pediatric use, systemic device‐trial challenges have impeded label expansion.
Mira C. Hasner, Faith C. Robertson, Nathaniel D. Sisterson, Gabriel Lazaro‐Munoz, Florence T. Bourgeois, James W. Wheless, Steven M. Wolf, Peter C. Warnke, Saadi Ghatan, Joffre Olaya, Catherine J. Chu, Brian N. Lundstrom, Sanjeev V. Kothare, Marytery Fajardo, Marike L. D. Broekman, R. Mark Richardson   +15 more
wiley   +1 more source

Video‐based diagnostics supported by artificial intelligence as an opportunity to address the epilepsy diagnostic gap: A narrative review

Epilepsia, EarlyView.
Abstract Despite advancements in epilepsy care, a substantial diagnostic gap persists, particularly in resource‐limited settings. This narrative review explores the potential of video‐based diagnostics augmented by artificial intelligence (AI) to address this gap by enabling earlier and more accessible seizure detection and classification.
Gadi Miron, Robert Terziev, Maximilian Schöls, John McLaren, Tobias Loddenkemper, Jörg Wellmer, Sigrid Mues, Christian Meisel   +7 more
wiley   +1 more source

Presurgical magnetoencephalography‐derived network control metrics distinguish successful hippocampal resection vs sparing in temporal lobe epilepsy

Epilepsia, EarlyView.
Abstract Objective Surgical decision‐making in temporal lobe epilepsy (TLE) faces a critical challenge in determining whether the hippocampus can be safely spared during anterior temporal resection, particularly when surgery involves the language‐dominant hemisphere.
Guhan Seshadri NP, Himanshu Kumar, Neha Sara John, Andreas V. Alexopoulos, Richard C. Burgess, Hiroatsu Murakami, Balu Krishnan   +6 more
wiley   +1 more source

Components of generalized onset seizures with focal evolution progressing to bilateral tonic–clonic seizures using quantitative electroencephalography in children: Focal or generalized?

Epilepsia, EarlyView.
Abstract Absence seizures evolving to bilateral tonic–clonic seizures may have focal or asymmetric clinical features. Using quantitative electroencephalography (EEG) may evaluate this phenomenon and the involved neuronal network. We conducted a retrospective chart review of pediatric patients with generalized epilepsy and normal brain magnetic ...
Juan Toro‐Perez, Erick Sell, Asif Doja, Ana Suller‐Marti, Katherine Muir, Sarah Healy, Srinivas Bulusu, Sharon Whiting, Roberto Caraballo   +8 more
wiley   +1 more source

Astrocyte subtype‐specific alterations in the dentate gyrus of individuals with mesial temporal lobe epilepsy

Epilepsia Open, EarlyView.
Abstract Objective Epilepsy affects approximately 50 million people worldwide and, although primarily attributed to neuronal dysfunction, increasing evidence highlights a critical role of glial cells, particularly astrocytes, in the pathophysiological mechanisms.
Chiara Lötzsch, Jakob Johann Schmidt, Daniel Delev, Roland Coras, Ingmar Blümcke, Ruth Beckervordersandforth   +5 more
wiley   +1 more source

Health Care Providers' Attitudes Toward Do-Not-Resuscitate Order in COVID-19 Patients: An Ethical Dilemma in Iran. [PDF]

Omega (Westport)
Mirhosseini S, Aghayan SS, Basirinezhad MH, Ebrahimi H.   +3 more
europepmc   +1 more source

Healthcare Professionals’ Experiences of Barriers and Facilitators to ARFID Identification, Diagnosis and Treatment: A Rapid Review

European Eating Disorders Review, EarlyView.
ABSTRACT Objectives Despite increasing evidence of the physical and psychosocial impairments associated with Avoidant/Restrictive Food Intake Disorder (ARFID), there are currently no national guidelines for its assessment and treatment. In the absence of such guidance, it is crucial to understand the experiences of healthcare professionals (HCPs ...
Sandra‐Eve Bamigbade, Freya Cooper, Amanda Ludlow   +2 more
wiley   +1 more source

Rethinking GABAergic therapy in neonatal seizures: Beyond Scylla and Charybdis

Epilepsia Open, EarlyView.
Raffaele Falsaperla, Vincenzo Sortino, Georgia Ramantani   +2 more
wiley   +1 more source