Results 31 to 40 of about 38,188 (263)

Divine Command Theory – a critical reflections

open access: yesIdei, 2018
The technological and cultural development of society brings urgent challenges of an interdisciplinary character that also exert an influence over the humanities. In the ethical discourse on current trends in moral reasoning, the metaethical theory known
Tibor Mahrik
doaj   +1 more source

Ethical criteria when a (potential) perpetrator asks a human rights organization to defend their case based on the forensic documentation of alleged torture. How shall we proceed?

open access: yesTorture, 2020
Objective Discuss the ethical dilemma of perpetrators requesting clinical evaluations intended to prove persecution or torture. The discussion is organized around three real cases.
Sara López Martín
doaj   +1 more source

A Spatially Directed Microneedle Patch Enables Intratumoral Co‐Delivery of FOLFIRINOX, Surufatinib, and Anti‐PD‐1 for Chemo‐Immunotherapy of Pancreatic Ductal Adenocarcinoma

open access: yesAdvanced Science, EarlyView.
A double‐layered shell‐core microneedle patch is developed to co‐deliver FOLFIRINOX, surufatinib, and anti‐PD‐1 for localized chemo‐immunotherapy of PDAC. This strategy achieves sustained tumor suppression, reduces metastasis, and reprograms the TME by enhancing CD8+ T‐cell infiltration and inhibiting Tregs and M2 macrophages infiltration, while ...
Tingting Kong   +13 more
wiley   +1 more source

The problem of lesser evil within the context of public health

open access: yesJournal of Education, Health and Sport, 2016
Sytnik-Czetwertyński Janusz, Cianciara Dorota. The problem of lesser evil within the context of public health. Journal of Education, Health and Sport. 2016;6(10):299-308. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.162532 http://ojs.ukw.edu.pl/
Janusz Sytnik-Czetwertyński   +1 more
doaj   +3 more sources

Ethical Dilemmas, Causes, and Countermeasures of Centralized Drug Procurement

open access: yesYixue yu zhexue
Centralized drug procurement is a key initiative in healthcare system reform. While it has successfully reduced costs and benefited the public, it has also triggered a range of ethical challenges.
Qiang XIONG
doaj   +1 more source

Who decides in withdrawal of treatment in a critical care setting? A case study on ethical dilemma

open access: yesInternational Journal of Nursing Sciences, 2018
Case description: Withdrawal of treatment is a common practice in critical care settings, perticularly when treatment is considered futile. The case study demonstrates an ethical dilemma, in which Danny is unlikely to make a functional recovery because ...
Chunmei Lyu, Li Zhang
doaj   +1 more source

Deciphering Anti‐Cancer Drug Efficacy Through Nanomechanical Vibrations in Living Gastric Cancer Organoids

open access: yesAdvanced Science, EarlyView.
This study developed an efficacy assessment platform that integrates patient‐derived gastric cancer organoids, atomic force microscopy (AFM)‐based nanomechanical vibration detection, deep learning analysis, and organoid mechanical modeling. It detects picomolar drug effects within 0.1 s signal, achieves 97% classification accuracy, and offers non ...
Ting Zhang   +10 more
wiley   +1 more source

Ethical Dilemmas and Governance Strategies for Research and Clinical Application of Proton Tumor Therapy

open access: yesYixue yu zhexue
Throughout the process from research and development to clinical translation, proton therapy for tumors continues to face unresolved issues regarding the management of safety risks and the attribution of responsibility.
Wen CAO, Wenbing MA, Shiyun ZHANG
doaj   +1 more source

Nanometer Layer Coating to Lactose Particles for Optimization of Dexamethasone Pulmonary Delivery

open access: yesAdvanced Science, EarlyView.
Nanometer layer coating (NLC) was investigated and its mechanism illustrated by advanced characterization techniques. The effects and application for the inhalation of dexamethasone (DEX) were demonstrated through in vitro and in vivo evaluation. This approach increased DEX bioavailability and enabled the dose to be reduced to 1/30 of the intravenous ...
Qin Nie   +11 more
wiley   +1 more source

Digital Dilemma 2018

open access: yesPapers from the Institute of Archaeology, 2020
To download this paper, please click here.In October 2018 a one-day conference was held at the UCL Institute of Archaeology focussing on the ‘Digital Dilemma’ in biological archaeology —specifically human remains research where the use of digitisation ...
doaj   +2 more sources

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